Joset, syrup 200 ml

Joset is a combined drug, it has bronchodilator, expectorant, mucolytic action.

– Salbutamol – bronchodilator, stimulates β2-adrenoreceptors of the bronchi, prevents or stops bronchospasm.

– Bromhexin is a mucolytic agent, has expectorant and mild anti-cough effects. Reduces the viscosity of sputum due to depolarization of acidic mucopolysaccharides and stimulation of secretory cells of the bronchial mucosa. Activates the cilia of the atomizing epithelium, improving the expectoration of sputum.

– Guaifenesin – reduces surface tension and adhesive properties of sputum, increases the serous component of bronchial secretion, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates sputum removal and promotes the transition of non-productive cough into productive.

Menthol – has an antispasmodic effect, gently stimulates the secretion of bronchial glands, has antiseptic properties, has a calming effect and reduces irritation of the mucous membrane of the airways.

Indications

Acute and chronic bronchopulmonary diseases accompanied by difficulty in phlegm discharge:
– bronchial asthma;
– chronic bronchitis;
– pulmonary emphysema;
– COPD;
– tracheobronchitis;
– pneumonia;
– pneumoconiosis;
– pulmonary tuberculosis.

Composition

5 ml of syrup contains:

salbutamol sulfate 1.205 mg, which corresponds to the content of salbutamol 1 mg,

bromhexine hydrochloride 2 mg,

guaifenesin 50 mg,

menthol (levomenthol) 500 µg,

excipients:

sodium methyl parahydroxybenzoate,

sodium propyl parahydroxybenzoate,

How to take, the dosage

The drug should be taken orally.

In children under 6 years of age – 1 tsp (5 ml) 3 times/day; from 6 to 12 years – 1 to 2 tsp (5-10 ml) 3 times/day.

Adults and children over 12 years – 2 tsp (10 ml) 3 times a day.

Interaction

Beta2-adrenomimetics, theophylline and other xanthines increase the likelihood of tachyarrhythmias when used concomitantly with the drug.

MoA inhibitors and tricyclic antidepressants increase the effect of salbutamol and may lead to a sharp decrease in BP.
Diuretics and GCS increase hypokalemic effect of salbutamol.

Simultaneous use with drugs containing codeine and other anti-cough medications makes it difficult to drain dilute sputum.

The bromhexin in the drug promotes penetration of antibiotics into the lung tissue.

It is not recommended to use simultaneously with non-selective β-adrenoreceptor blockers.

Special Instructions

Guifenesin stains the urine pink.

It is not recommended to wash the drug with alkaline drinks.

Contraindications

– tachyarrhythmia;
– myocarditis;
– aortic stenosis;
– decompensated diabetes;
– thyrotoxicosis;
– glaucoma;
– hepatic and/or renal insufficiency;
– Gastric and duodenal ulcer in the acute phase;
– Gastric bleeding;
– pregnancy;
– lactation (breast-feeding);
– hypersensitivity to Components of the preparation Joset.
With caution the drug should be used in case of diabetes mellitus, arterial hypertension, peptic ulcer in anamnesis; simultaneously with anticough agents, non-selective β-adrenoreceptor blockers, MAO inhibitors.

Side effects

CNS disorders: headache, dizziness, increased nervous excitability, sleep disturbance, somnolence, tremors, convulsions.

In the digestive system: nausea, vomiting, diarrhea, exacerbation of gastric and duodenal ulcer; very rarely – increased liver transaminase activity.

Cardiovascular system: tachycardia, decreased BP, collapse.

Urinary system disorders: staining of urine pink.

Allergic reactions: skin rash, urticaria, paradoxical bronchospasm.

Overdose

Symptoms: increased manifestation of side effects.

Treatment: symptomatic therapy.