Isoket, concentrate 1 mg/ml 10 ml 10 pcs

Isoket – hypotensive, antianginal.

Pharmacodynamics

Peripheral vasodilator with predominant effect on the venous vessels. Stimulates the formation of nitric oxide (endothelial relaxing factor) in the vascular endothelium, causing activation of intracellular guanylate cyclase, the consequence of which is an increase of cGMP (mediator of vasodilation). Reduces myocardial oxygen demand by reducing preload (reduces left ventricular end-diastolic volume and reduces systolic stress on its walls). It has coronary dilator effect.

Limits blood flow to the right atrium, helps decrease the pressure in the small circle of the blood circulation and regresses symptoms of pulmonary edema.

Promotes redistribution of coronary blood flow to areas with decreased blood flow. Increases tolerance to physical activity in patients with coronary heart disease, angina pectoris. It dilates the vessels of the brain, dura mater, which may be accompanied by headache.

As with other nitrates, cross-tolerance develops. After withdrawal (interruption of treatment), sensitivity to it quickly recovers. After spraying on the oral mucosa, the effect is evident in 30 seconds and lasts 15-120 minutes.

Indications

attacks of all forms of angina
prevention of angina pectoris
acute myocardial infarction
chronic heart failure.

Pharmacological effect

ISOKET – hypotensive, antianginal.

Pharmacodynamics

Peripheral vasodilator with a predominant effect on venous vessels. Stimulates the formation of nitric oxide (endothelial relaxing factor) in the vascular endothelium, which causes activation of intracellular guanylate cyclase, resulting in an increase in cGMP (a mediator of vasodilation). Reduces myocardial oxygen demand by reducing preload (reduces the end-diastolic volume of the left ventricle and reduces the systolic tension of its walls). Has a coronary dilating effect.

Reduces blood flow to the right atrium, helps reduce pressure in the pulmonary circulation and regression of symptoms of pulmonary edema.

Promotes redistribution of coronary blood flow in areas with reduced blood circulation. Increases exercise tolerance in patients with coronary artery disease and angina pectoris. Dilates blood vessels in the brain and dura mater, which may be accompanied by headaches.

As with other nitrates, cross-tolerance develops. After cancellation (break in treatment), sensitivity to it is quickly restored. After spraying onto the oral mucosa, the effect appears within 30 seconds and lasts 15–120 minutes.

Special instructions

When using the drug Izoket, you should monitor indicators of the cardiovascular system: blood pressure control (systolic blood pressure not lower than 100 mm Hg), ECG monitoring, heart rate, urine output (bladder catheterization).

Since the 0.1% Isoket solution is a supersaturated solution, crystallization of the substance may occur. Despite the fact that under normal conditions this does not affect the activity of the drug, in case of crystallization the solution is not recommended to be used.

Active ingredient

Isosorbide dinitrate

Composition

Active ingredient:

isosorbide dinitrate 10 mg.

Contraindications

acute phase of myocardial infarction
marked decrease in blood pressure
hypersensitivity to the drug Isoket

Side Effects

From the cardiovascular system: upon first use or when increasing the dose of the drug, a decrease in blood pressure and/or orthostatic hypotension is possible, which may be accompanied by a reflex increase in heart rate, lethargy, as well as dizziness and a feeling of weakness. At the beginning of treatment, a headache (“nitrate” headache) may appear, which, as a rule, disappears after a few days with further use of the drug. In rare cases, with a pronounced decrease in blood pressure, an increase in the symptoms of angina pectoris may be observed.

In isolated cases, collaptoid states are observed, sometimes with bradycardia and syncope (attacks with impaired consciousness, dizziness associated with cerebrovascular accident as a result of heart rhythm disturbances, primarily due to its significant slowdown).

From the digestive system: rarely – nausea, vomiting.

Other: redness of the skin, allergic skin reactions; in some cases – exfoliative dermatitis.

Interaction

With simultaneous use of Isoket with other vasodilators (vasodilators), antihypertensive drugs, beta-blockers, calcium channel blockers, phosphodiesterase type 5 inhibitors used to treat erectile dysfunction (for example, sildenafil), antipsychotics, tricyclic antidepressants, as well as ethanol, the hypotensive effect may be enhanced

With simultaneous use of Isoket with dihydroergotamine, an increase in the concentration of dihydroergotamine in the blood may be observed, which leads to an increase in its hypotensive effect.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Manufacturer

UCB Farma, Belgium