Iodoxide, vaginal suppositories 200 mg 10 pcs

Antiseptic drug. It blocks amino groups of cellular proteins. It has a wide range of antimicrobial action. It is active against bacteria (including E. coli, Staphylococcus aureus), fungi, viruses, protozoa.

The active ingredient of the drug – iodine – is in the form of complex with polyvinylpyrrolidone (povidon), related to iodophores that bind iodine. Concentration of active iodine is 0.1-1%.

In contact with skin and mucous membranes iodine is gradually and evenly released with bactericidal effect on microorganisms.

A thin colored layer remains on the application site until all iodine is released.

Absorption and distribution

In contact with the mucous membranes povidone-iodine may be absorbed and its content in the blood (concentration returns to the initial value in 7-14 days after the last use of the drug).

In patients with normal thyroid function increased absorption of iodine does not cause significant changes in its hormonal function.

Excretion

Iodine is excreted mainly by the kidneys. The half-life (T1/2) after intravaginal administration is about 48 hours.

Indications

acute and chronic infectious and inflammatory diseases of the vagina (trichomoniasis, fungal, viral, nonspecific, mixed infections);
bacterial vaginitis;
prevention of infectious and inflammatory complications before gynecological interventions (artificial termination of pregnancy, installation and removal of an intrauterine device, diathermocoagulation of the cervix, hysterosalpingography and others).

Pharmacological effect

Antiseptic drug. Blocks amino groups of cellular proteins. Has a wide spectrum of antimicrobial action. Active against bacteria (including Escherichia coli, Staphylococcus aureus), fungi, viruses, protozoa.

The active substance of the drug – iodine – is in the form of a complex with polyvinylpyrrolidone (povidone), which belongs to iodophors that bind iodine. The concentration of active iodine is 0.1-1%.

Upon contact with the skin and mucous membranes, iodine is gradually and evenly released, exerting a bactericidal effect on microorganisms.

A thin colored layer remains at the site of application, which remains until all the iodine is released.

Suction and distribution

When povidone-iodine comes into contact with the mucous membrane, iodine may be absorbed and its content in the blood may increase (the concentration returns to its original value 7-14 days after the last use of the drug).

In patients with normal thyroid function, increased iodine absorption does not cause significant changes in thyroid hormonal function.

Removal

Iodine is excreted primarily by the kidneys. The half-life (T1/2) after intravaginal use is approximately 48 hours.

Special instructions

In the presence of blood, the bactericidal effect of povidone-iodine may be reduced.

In the case of non-manifest hyperthyroidism and other diseases of the thyroid gland (especially in elderly patients), the drug is used only according to strict indications and under constant medical supervision.

Due to the oxidizing properties of povidone-iodine, trace amounts may cause false-positive results in some types of tests to detect occult blood in the stool and blood or glucose in the urine.

During use of povidone-iodine, iodine uptake by the thyroid gland may be decreased, which may affect the results of some diagnostic tests (eg, thyroid scintigraphy,

determination of protein-bound iodine, measurements using radioactive iodine), and possible interaction with iodine preparations used to treat thyroid diseases.

To obtain undistorted results of thyroid scintigraphy after long-term therapy with povidone-iodine, it is recommended to maintain a sufficiently long period of time without this drug.

If symptoms of hyperthyroidism occur during treatment, thyroid function should be checked.

Caution should be exercised when using the drug regularly in patients with previously diagnosed renal failure.

Regular use of Iodoxide® should be avoided in patients receiving lithium preparations.

Caution is recommended when administering vaginal suppositories to virgins.

Coloring on leather and fabrics is easily washed off with water.

Suppositories have a spermicidal effect, and therefore their use is not recommended for people planning pregnancy.

During the use of suppositories, the use of sanitary pads can be recommended.

After contact with the drug, avoid contact with the eyes.

Impact on the ability to drive vehicles and operate machinery

Does not affect the ability to drive a car or use other machinery.

Active ingredient

Povidone-Iodine

Composition

Active substance:

Povidone-iodine (povidone-iodine 30/06) – 200.0 mg (with povidone-iodine activity 11%; in case of other drug activity, reduce or increase the amount of base accordingly);

Excipients:

Polyethylene oxide base:

Macrogol-1500 (polyethylene oxide-1500) – 2.66 g,

Macrogol-400 (polyethylene oxide-400) – 0.14 g.

Contraindications

hypersensitivity to the components of the drug;
thyrotoxicosis;
Dühring’s dermatitis herpetiformis;
thyroid adenoma;
simultaneous therapy with radioactive iodine;
neonatal period (especially in premature babies).

With caution:

chronic renal failure;
pregnancy (II and III trimester);
breast-feeding.

Side Effects

Hypersensitivity reactions to the drug at the site of application: hyperemia, itching.

Allergic reactions are possible, including contact dermatitis with the formation of psoriasis-like red small bullous elements.

If such phenomena occur, use of the drug should be discontinued.

Interaction

Povidone-iodine is incompatible with oxidizing agents, alkali salts and acidic substances.

It is not recommended to use povidone-iodine simultaneously with hydrogen peroxide and products containing mercury, silver and enzymes.

Storage conditions

In a place protected from light at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use the drug after the expiration date indicated on the package.

Manufacturer

Nizhpharm JSC, Russia