Iodilife, tablets 28 pcs
€14.25 €12.47
Pharmacological group
ATC code: A11E
B vitamins + other drugs
Pharmacological action
Folic acid refers to B vitamins. In the body, folic acid is reduced to tetrahydrofolic acid, which is involved in the synthesis of purines and pyrimidines, choline metabolism, in general – in the metabolism of nucleic acids and proteins. It plays an important role in the formation of the central nervous system, which develops in humans on day 15-28 after fertilization. Deficiency of folic acid causes the development of neural tube defects in the fetus.
Vitamin B12 exists inside the cell as two active coenzymes: methylcobalamin and adenosylcobalamin. Methylcobalamin is essential for methionine synthetase, which is involved in the metabolism of folic acid. This interaction of folic acid with cobalamin is necessary for normal synthesis of purines and pyrimidines, and therefore DNA. In vitamin B12 or folic acid deficiency, reduced synthesis of methionine and S-adenosylmethionine impairs many methylation reactions, protein and polyamine synthesis.
400 micrograms of folic acid is the minimum effective daily dose recommended by the Centers for Disease Prevention (US, UK and Australia) for healthy women as an additional daily intake to prevent neural tube defects in the fetus. The recommended daily intake of vitamin B12 is 2 micrograms.
Iodine is the basic element for the synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3) (which have an iodine mass fraction of 65% and 59%, respectively). Thyroid hormones are necessary at all stages of life for normal functioning of the central nervous system (CNS).
Pharmacokinetics
Folic acid is rapidly absorbed in the jejunum, undergoing reduction and methylation to 5-methyltetrahydrofolate. The maximum concentration in plasma is observed after 30-60 minutes.
It binds intensively with plasma proteins. It penetrates through the blood-brain barrier, into the placenta and the breast milk. It is excreted by the kidneys mainly as metabolites. Vitamin B12 can be absorbed after its interaction in the stomach with intrinsic factor Kahl, a glycoprotein that is secreted by the parietal cells of the stomach. Maximum plasma concentrations are observed after 8-12 hours. As with folic acid, vitamin B12 undergoes significant intestinal-hepatic recirculation.
The average half-life of vitamin B12 is about 6 days. Part of the administered dose is excreted by the kidneys during the first 8 hours, although most is excreted with the bile. 25% is excreted through the intestines. In addition, vitamin B12 passes through the placenta and is present in the mother’s milk.
Vitamin B12 is largely bound to plasma proteins, the excess accumulates in the liver.
Iodine has good absorption. The intestinal absorption rate of iodine after ingestion of water-soluble iodine salts (e.g., potassium iodide) is thought to be 100%. The mechanism of intestinal absorption of iodine is not known.
After completion of the absorption process, iodine spreads rapidly through the intercellular fluid. Iodine penetrates the placental barrier and is present in the mother’s milk. Iodine is transported to other tissues (except thyroid tissue): mammary/salivary gland and intestinal mucosa.
The bulk of iodine is excreted by the kidneys and a small amount with saliva, milk, sweat, bile and through the intestine.
Indications
Prevention of iodine, folic acid and vitamin B12 (cyanocobalamin) deficiency in women of childbearing age during the planning stage of pregnancy (at least 1 month before conception).
How to take, the dosage
One tablet a day, before meals.
Interaction
Iodilife should not be taken in combination with methotrexate, pyrimethamine, triamterene, trimethoprim, because they act as folic acid antagonists, inhibiting tetrahydrofolate reductase.
Special Instructions
It should be borne in mind that antibiotics can distort (give lower results) the results of the analysis of the concentration of plasma folic acid and red blood cells.
Due to the effect of iodides on the thyroid gland, taking these drugs can lead to distorted results of thyroid function tests.
The double dose should not be taken if the next dose is missed.
The drug does not affect the performance of potentially hazardous activities requiring particular attention and quick reactions (driving vehicles, operating moving mechanisms, operator’s work, etc.).
Contraindications
Individual hypersensitivity to the ingredients of the drug, lactation, pediatric age.
The drug contains lactose. The drug is contraindicated in patients with hereditary galactose intolerance, lactase deficiency or disorders of glucose or galactose absorption.
At a daily dose of more than 150 mg/day, potassium iodide is contraindicated in patients with acute bronchitis, severe and latent hyperthyroidism.
With caution
Patients with: hypocomplementemic vasculitis, goiter or autoimmune thyroiditis, kidney disease, chronic hyperkalemia, active tuberculosis, epilepsy are cautionary patients.
Overdose
If you overdose or accidentally swallow the drug, you should immediately consult a doctor.
Pregnancy use
The drug is recommended for use during pregnancy. The drug components penetrate into the breast milk. Since there are currently no data on the use of the drug during this period, the drug is not recommended for use during breast-feeding.
Weight | 0.012 kg |
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Shelf life | 3 years. |
Conditions of storage | At a temperature not exceeding 25°C. |
Manufacturer | Italpharmaco S.p.A., Italy |
Medication form | pills |
Brand | Italpharmaco S.p.A. |
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