Indomethacin 50 Berlin-Chemie, rectal 50 mg 10 pcs

Pharmacodynamics

The drug from the group of NSAIDs, has anti-inflammatory, analgesic, antipyretic and anti-aggregation effects. Inhibits the activity of pro-inflammatory factors and reduces platelet aggregation.

Inhibiting cyclooxygenase 1 and 2 it disrupts arachidonic acid metabolism, decreases quantity of prostaglandins (Pg) both in inflammation focus and in healthy tissues, inhibits exudative and proliferative phases of inflammation. It causes easing or disappearance of pain syndrome of rheumatic and non-rheumatic character (including joint pain at rest and on movement, decrease of morning stiffness and joint swelling, promotes increase of movement capacity; at inflammatory processes arising after operations and traumas, quickly relieves spontaneous pain as well as pain on movement, reduces inflammatory swelling of the wound area).

Pharmacokinetics

Absorption is fast. Bioavailability by rectal route of administration is 80-90%. Binding to plasma proteins is 90%, T1/2 is 4-9 hours. Metabolized mainly in the liver, 30% of the drug is excreted unchanged. It is eliminated by the kidneys for 70% and by the intestines for 30%. It is not eliminated during dialysis. It penetrates into the breast milk.

Indications

Joint syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout); spine pain, neuralgia, myalgia, traumatic inflammation of soft tissue and musculoskeletal system; rheumatism, diffuse connective tissue diseases; dysmenorrhea.

As an aid in infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.

Active ingredient

Composition

Active ingredients:

Indomethacin 50 mg.

Auxiliary substances:

fat – 800 mg,

corn starch – 100 mg.

How to take, the dosage

Rectally (inserted into the rectum). Before using the suppository it is recommended to empty the intestines.

Adults suppositories 100 mg 1 suppository 1 time/day; suppositories 50 mg 1 suppository 1-3 times/day.

In a gout attack up to 200 mg/day.

Interaction

Decreases the effectiveness of uricosuric drugs, hypotensive drugs and diuretics (saluretics); increases the effect of indirect anticoagulants, antiaggregants, fibrinolytics, the side effects of mineralocorticosteroids, estrogens, etc. NSAIDs; increases the hypoglycemic effect of sulfonylurea derivatives.

Combined use with paracetamol increases the risk of nephrotoxic effects. Ethanol, colchicine, glucocorticosteroids increase the risk of gastrointestinal complications accompanied by bleeding.

It increases the blood concentration of lithium, methotrexate and digoxin.

Cyclosporine, gold drugs increase nephrotoxicity of indomethacin. Cefamandole, cefoperazone, valproic acid – increase the risk of hypoprothrombinemia and the risk of bleeding. Reduces the elimination of penicillins. Potentiates the toxic effects of zidovudine.

Special Instructions

At the time of treatment, peripheral blood counts and liver and kidney function should be monitored. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

When treating the drug it is necessary to refrain from driving motor transport and engaging in potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Gastric and duodenal ulcer; ulcerative colitis; bleeding (intracranial, gastrointestinal); congenital heart defects (coarctation of the aorta, pulmonary atresia, Fallot tetrad); heart failure; arterial hypertension; color vision disorder; optic nerve disease; liver cirrhosis with portal hypertension; liver failure; Bronchial asthma; hemophilia, hypocoagulation, other blood disorders; chronic renal insufficiency; hearing loss; vestibular pathology; glucose-6-phosphate dehydrogenase deficiency; proctitis, hemorrhoids; pregnancy and lactation; children and adolescents under 18; hypersensitivity to indomethacin and other NSAIDs, includingincluding “aspirin” asthma.

With caution: in hyperbilirubinemia, thrombocytopenia, epilepsy, parkinsonism, depression and in elderly patients.

Side effects

Gastrointestinal system: NSAIDs-gastropathy, abdominal pain, nausea, vomiting, heartburn, anorexia, diarrhea, liver dysfunction (increase in blood bilirubin, “hepatic” transaminases). With long-term use in high doses – ulceration of the mucous membrane of the gastrointestinal tract.

Nervous system disorders: headache, dizziness, insomnia, agitation, irritability, fatigue, sleepiness, depression, peripheral neuropathy.

Sensory organs: decreased hearing, tinnitus, taste disorders, diplopia, blurred vision, corneal clouding, conjunctivitis.

Cardiovascular system: heart failure, tachyarrhythmia, increased BP.

Urinary system disorders: impaired renal function, proteinuria, hematuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.

Hemostatic system disorders: bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), thrombocytopenia.

Allergic reactions: skin rash, pruritus, urticaria, Quincke’s edema, bronchospasm; Lyell syndrome, erythema nodosa, anaphylactic shock are rare.

Hematopoietic system disorders: agranulocytosis, leukopenia, aplastic anemia, autoimmune hemolytic anemia.

Metabolic system: hyperglycemia, glucosuria.

Water-electrolyte balance: hyperkalemia.

Others: aseptic meningitis (more often in patients with autoimmune diseases), increased sweating, edema syndrome.

Local reactions: burning, itching, heaviness in the anorectal area, exacerbation of hemorrhoids.

Overdose

Symptoms: Nausea, vomiting, severe headache, dizziness, memory impairment, disorientation. In severe cases, paresthesias, numbness of extremities, seizures.

Treatment:Symptomatic therapy is carried out. Hemodialysis is ineffective.

Pregnancy use

The drug is contraindicated in pregnancy and during breastfeeding.

Similarities