Indomethacin, 25 mg 30 pcs

Indomethacin has anti-inflammatory, analgesic and antipyretic, as well as some antiaggregant action.

Inhibits the activity of anti-inflammatory factors, reduces platelet aggregation. Inhibiting cyclooxygenase 1 and 2, disrupts arachidonic acid metabolism, reduces the amount of prostaglandins (Pg) both in the focus of inflammation and in healthy tissues, suppresses exudative and proliferative phases of inflammation.

When used topically it causes alleviation or disappearance of pain syndrome of rheumatic and non-rheumatic character (including In case of pain of the joints at rest and when moving, it reduces morning stiffness and swelling of the joints, increases the range of motion; in case of inflammatory processes after operations and injuries, it quickly relieves spontaneous pain as well as pain while moving, reduces inflammatory swelling of the wound area).

Indications

For systemic use: joint syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), spine pain, neuralgia, myalgia, traumatic inflammation of soft tissue and joints, rheumatism, diffuse connective tissue diseases, dysmenorrhea. As an adjunctive agent in infectious-inflammatory diseases of the ENT-organ, adnexitis, prostatitis, cystitis.

For local use: prophylaxis of inflammation during cataract and anterior segment surgery, myositis inhibition during surgery.

Active ingredient

Composition

Ecocoated tablets are white or almost white, round, biconvex; the fracture of the tablet shows two layers – white or white with a yellowish tint and a film coating.

Associates:

Lactose monohydrate 41.6 mg,

Potato starch 10 mg,

Microcrystalline cellulose 16 mg,

Povidone 2.5 mg,

magnesium stearate 0.9 mg.

Composition of the film coating:

Cellacephate 2.2 mg, polysorbate-80 0.72 mg, titanium dioxide 1.08 mg.

How to take, the dosage

Special Instructions

With caution, use in elderly patients, as well as in patients with a history of liver, renal, GI diseases, dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after major surgical interventions, with parkinsonism, epilepsy.

When a history of allergic reactions to NSAIDs is indicated, use only in emergency cases.

During treatment, systematic monitoring of liver and renal function, peripheral blood picture is required.
Simultaneous use with acetylsalicylic acid and other NSAIDs is not recommended.

Indomethacin should not be used concomitantly with diflunisal.

In concomitant use of indomethacin with lithium preparations, be aware of the possibility of symptoms of lithium toxicity.

When used topically, do not apply to the wounded surface of the skin, and avoid contact with the eyes or mucous membranes.

Impact on driving and operating machinery

At any time during treatment, avoid potentially hazardous activities requiring concentration and increased speed of psychomotor reactions.

Contraindications

Side effects

Overdose

Symptoms: nausea, vomiting, severe headache, dizziness, memory impairment, disorientation. In severe cases paresthesias, numbness of extremities, convulsions.

Treatment: symptomatic therapy. Hemodialysis is ineffective.

Similarities