Indomethacin, 25 mg 30 pcs

Indomethacin has anti-inflammatory, analgesic and antipyretic, as well as some antiaggregant action.

Inhibits the activity of anti-inflammatory factors, reduces platelet aggregation. Inhibiting cyclooxygenase 1 and 2, disrupts arachidonic acid metabolism, reduces the amount of prostaglandins (Pg) both in the focus of inflammation and in healthy tissues, suppresses exudative and proliferative phases of inflammation.

When used topically it causes alleviation or disappearance of pain syndrome of rheumatic and non-rheumatic character (including In case of pain of the joints at rest and when moving, it reduces morning stiffness and swelling of the joints, increases the range of motion; in case of inflammatory processes after operations and injuries, it quickly relieves spontaneous pain as well as pain while moving, reduces inflammatory swelling of the wound area).

Indications

For systemic use: articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissues and joints, rheumatism, diffuse connective tissue diseases, dysmenorrhea. As an adjuvant for infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.

For local use: prevention of the inflammatory process during surgery for cataracts and on the anterior segment of the eye, inhibition of miosis during surgery.

Pharmacological effect

Indomethacin has anti-inflammatory, analgesic and antipyretic, as well as some antiplatelet effects.

Suppresses the activity of anti-inflammatory factors, reduces platelet aggregation. By inhibiting cyclooxygenase 1 and 2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (Pg) both in the site of inflammation and in healthy tissues, and suppresses the exudative and proliferative phases of inflammation.

When used externally, it causes a weakening or disappearance of pain of a rheumatic and non-rheumatic nature (including pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints, helps to increase the range of movements; in inflammatory processes that occur after operations and injuries, quickly relieves both spontaneous pain and pain during movement, reduces inflammatory swelling at the wound site).

Special instructions

Use with caution in elderly patients, as well as with a history of liver, kidney, gastrointestinal diseases, dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after major surgical interventions, parkinsonism, epilepsy.

If there is a history of allergic reactions to NSAIDs, they are used only in emergency cases.

During the treatment period, systematic monitoring of liver and kidney function and peripheral blood patterns is necessary.
Concomitant use with acetylsalicylic acid and other NSAIDs is not recommended.

Indomethacin should not be used simultaneously with diflunisal.

When using indomethacin simultaneously with lithium preparations, one should keep in mind the possibility of symptoms of lithium toxicity.

When applied topically, it should not be applied to the wounded surface of the skin, and also avoid contact with the eyes or mucous membranes.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, you should refrain from potentially hazardous activities associated with the need for concentration and increased speed of psychomotor reactions.

Active ingredient

Indomethacin

Composition

Enteric-coated tablets are white or almost white, round, biconvex; on the break of the tablet two layers are visible – a white or white core with a yellowish tint and a film shell.

1 tab.
indomethacin
25 mg

Excipients:

lactose monohydrate 41.6 mg,

potato starch 10 mg,

microcrystalline cellulose 16 mg,

povidone 2.5 mg,

magnesium stearate 0.9 mg.

Film shell composition:

cellacephate 2.2 mg, polysorbate-80 0.72 mg, titanium dioxide 1.08 mg.

Contraindications

Hypersensitivity to indomethacin, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, “aspirin triad”, hematopoietic disorders, severe liver and/or kidney dysfunction, severe forms of chronic heart failure, arterial hypertension, pancreatitis, third trimester of pregnancy, children under 14 years of age; for rectal use: proctitis, recent bleeding from the rectum.

Side Effects

From the digestive system: nausea, anorexia, vomiting, pain and discomfort in the abdomen, constipation or diarrhea, erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract; rarely – intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or from a diverticulum, jaundice, hepatitis.

Overdose

Symptoms: nausea, vomiting, severe headache, dizziness, memory impairment, disorientation. In severe cases, paresthesia, numbness of the limbs, convulsions.

Treatment: symptomatic therapy. Hemodialysis is ineffective.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

5 years

Manufacturer

Sopharma JSC, Bulgaria