Indapamide CF Stada, 1.5 mg 30 pcs

Hypotensive agent (diuretic, vasodilator). Pharmacological properties are close to thiazide diuretics (disrupts sodium ions reabsorption in the cortical segment of the Genle loop).

It increases urinary excretion of sodium and chlorine ions and, to a lesser extent, potassium and magnesium ions accompanied with intensification of diuresis.

With its ability to selectively block “slow” calcium channels it increases arterial wall elasticity and decreases total peripheral vascular resistance.

It promotes reduction of left ventricular hypertrophy.

It does not affect the content of plasma lipids (triglycerides, low-density lipoproteins, high-density lipoproteins); it does not affect carbohydrate metabolism (including in patients with diabetes).

It decreases sensitivity of vascular wall to noradrenalin and angiotensin II, stimulates synthesis of prostaglandin E2 and prostacyclin PGI2, decreases production of free and stable oxygen radicals.

Indapamide produces hypotensive effect in doses without a marked diuretic effect. Hypotensive effect develops by the end of the first week and lasts for 24 hours after a single dose.

Pharmacokinetics

After oral administration it is quickly and completely absorbed from the gastrointestinal tract; bioavailability is high (93%).

Food intake slightly slows down the absorption rate, but does not affect the amount absorbed.

Maximum concentration in plasma is reached 12 hours after oral administration. With repeated doses the fluctuations in plasma concentration of the drug in the interval between two doses are reduced.

The equilibrium concentration is established after 7 days of regular use. The half-life is 18 hours, the blood plasma protein binding is about 79%.

It also binds with elastin of smooth muscles of the vascular wall. It has a high volume of distribution, passes through the histohematic barriers (including the placental barrier), penetrates into breast milk.

Metabolized in the liver. The kidneys excrete 60-80% as metabolites (about 5% is excreted unchanged), through the intestines – 20%.

In patients with renal insufficiency pharmacokinetics is not changed. It does not cumulate.

Indications

Active ingredient

Composition

1 tablet contains:

The active ingredient:

Indapamide – 1.5 mg;

Associates:

Hypromellose (hypromellose 4000) – 42-78.4 mg;

Lactose monohydrate – 168.5-132.1 mg;

Colloidal silicon dioxide (aerosil) – 1 mg;

Magnesium stearate – 2 mg;

Shell:

Hypromellose (hydroxypropyl methylcellulose) – 5.94 mg;

Macrogol (polyethylene glycol 4000) – 1.29 mg;

Talc, 0.462 mg;

Titanium dioxide, 1.29 mg;

Tropelin O dye, 0.018 mg.

How to take, the dosage

Tablets are taken orally at 1.5 mg once daily (in the morning).

If hypotensive effect is not sufficient after 2 weeks of treatment, the dose is increased to 5-7.5 mg/day.

Maximum dose: 10 mg/day in 2 doses (in the morning).

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

Pregnancy use

Indapamide MB is not recommended during pregnancy and lactation.

Similarities