Hydrocortisone, eye ointment 0.5% 3 g

Pharmgroup:

Glucocorticosteroid for topical use.

Pharmic action:

HKS, has anti-inflammatory and anti-allergic effects.

Reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes to the area of inflammation.

Stabilizes cellular and subcellular, including lysosomal membranes and membranes of mast cells. Reduces Ig binding to receptors on cell surface and inhibits synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages.

Creases exudative reaction, helps to reduce capillary permeability.
Reduces the severity of the early immunological response.

It has an antimetabolic effect and inhibits the development of connective tissue and scarring.

Indications

Active ingredient

Composition

Active substance:

Hydrocortisone acetate – 0.5 g;

Auxiliary substances:

methylparahydroxybenzoate (methylparaben),

Vaseline.

How to take, the dosage

Topically. 1-2 cm of eye ointment is injected into the conjunctival sac 2-3 times a day.

The course of treatment is 1 – 2 weeks. The course of treatment can be prolonged upon the doctor’s recommendation.

Interaction

In prolonged use of the drug with possible resorption of the drug into the general bloodstream, hydrocortisone reduces the effectiveness of insulin, oral hypoglycemic drugs, hypotensive agents, anticoagulants, reduces the concentration of salicylates in blood, reduces the concentration of praziquantel in blood serum.

Add to the risk of side effects of hydrocortisone: Androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotics, carbutamide, azathioprine (cataracts); choline blockers, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia). When used with cardiac glycosides, development of digitalis intoxication is possible.

Simultaneous use with preparations of lead and silver leads to mutual inactivation.

Special Instructions

Wearing contact lenses is not recommended during treatment. When using eye drops the time interval between their instillation and application of the ointment – at least 15 minutes. When using for more than 10 days and if there is a history of open- or closed-angle glaucoma it is necessary to monitor the intraocular pressure. Shelf life after opening the tube – 1 month.

Influence on the ability to drive vehicles and operate machinery.

If after using the drug the patient’s vision is temporarily reduced, until its recovery it is not recommended to drive vehicles and engage in activities that require clarity of vision.

Contraindications

Side effects

Allergic reactions, burning, injected sclerae, momentary blurring of vision.

When prolonged use for more than 10 days may be observed:

– increased intraocular pressure with possible subsequent development of steroid glaucoma with optic nerve damage and visual field disruption (therefore, when using glucocorticosteroid-containing drugs for more than 10 days, intraocular pressure should be measured regularly);

– formation of posterior subcapsular cataracts;

– slowing of the wound healing process (in diseases that cause thinning of the cornea, its perforation is possible). Secondary bacterial infection may arise as a consequence of suppression of the protective reaction of the patient’s body. In acute purulent diseases of the eye, glucocorticosteroids may mask or intensify an existing infectious process.

Fungal corneal lesions tend to occur particularly often with long-term use of glucocorticosteroids. The appearance of non-healing ulcers on the cornea after long-term treatment with glucocorticosteroids may indicate the development of a fungal infestation.

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