Hydrocortisone, eye ointment 0.5% 3 g

Pharmgroup:

Glucocorticosteroid for topical use.

Pharmic action:

HKS, has anti-inflammatory and anti-allergic effects.

Reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes to the area of inflammation.

Stabilizes cellular and subcellular, including lysosomal membranes and membranes of mast cells. Reduces Ig binding to receptors on cell surface and inhibits synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages.

Creases exudative reaction, helps to reduce capillary permeability.
Reduces the severity of the early immunological response.

It has an antimetabolic effect and inhibits the development of connective tissue and scarring.

Indications

allergic eye diseases (eyelid dermatitis, blepharitis, conjunctivitis and keratoconjunctivitis);
inflammatory diseases of the eyes of the anterior part of the eye in the absence of a violation of the integrity of the corneal epithelium (blepharitis, conjunctivitis and keratoconjunctivitis);
thermal and chemical burns (after complete epithelization of corneal defects).

Pharmacological effect

Pharmaceutical group:

glucocorticosteroid for local use.

Pharmaceutical action:

GCS has anti-inflammatory and antiallergic effects.

Reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes to the area of ​​inflammation.

Stabilizes cellular and subcellular, incl. lysosomal membranes and mast cell membranes. Reduces the binding of Ig to receptors on the cell surface and inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages.

Reduces the exudative reaction, helps reduce capillary permeability.
Reduces the severity of the early immunological response.

It has an antimetabolic effect and inhibits the development of connective tissue and scarring.

Special instructions

Wearing contact lenses is not recommended during treatment. When using eye drops, the time interval between their instillation and application of the ointment is at least 15 minutes. When used for more than 10 days and if there is a history of open- or closed-angle glaucoma, monitoring of intraocular pressure is necessary. Shelf life after opening the tube is 1 month.

Influence on the ability to drive vehicles and operate machinery.

If the patient’s vision clarity is temporarily reduced after using the drug, it is not recommended to drive a car or engage in activities that require clarity of visual perception until it is restored.

Active ingredient

Hydrocortisone

Composition

Active ingredient:

hydrocortisone acetate – 0.5 g;

Excipients:

methyl parahydroxybenzoate (methylparaben),

petrolatum.

Contraindications

purulent, viral, tuberculosis, fungal eye diseases;
glaucoma;
trachoma;
vaccination period;
violation of the integrity of the membranes of the eye

Side Effects

Allergic reactions, burning, scleral injection, short-term blurred vision.

With prolonged use for more than 10 days, the following may occur:

– increased intraocular pressure with the possible subsequent development of steroid glaucoma with damage to the optic nerve and impairment of visual fields (therefore, when using drugs containing glucocorticosteroids, intraocular pressure should be regularly measured for more than 10 days);

– formation of posterior subcapsular cataract;

– slowing down the wound healing process (in diseases that cause thinning of the cornea, its perforation is possible). Secondary bacterial infection can occur as a result of suppression of the patient’s protective reaction. In acute purulent diseases of the eye, glucocorticosteroids can mask or intensify the existing infectious process.

Fungal infections of the cornea tend to occur especially frequently with long-term use of glucocorticosteroids. The appearance of non-healing ulcers on the cornea after long-term treatment with glucocorticosteroids may indicate the development of fungal invasion.

Interaction

With long-term use of the drug, with possible resorption of the drug into the general bloodstream, hydrocortisone reduces the effectiveness of insulin, oral hypoglycemic drugs, antihypertensive drugs, anticoagulants, reduces the concentration of salicylates in the blood, and reduces the concentration of praziquantel in the blood serum.

Increase the risk of developing side effects of hydrocortisone: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotics, carbutamide, azathioprine (cataracts); anticholinergics, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia). When used with cardiac glycosides, digitalis intoxication may develop.

Simultaneous use of lead and silver with preparations leads to mutual inactivation.

Storage conditions

At a temperature not exceeding 15 °C

Shelf life

2 years

Manufacturer

Pharmaceutical plant Elfa A.O., Poland