Hepone, lyophilizate 2 mg
€34.29 €28.58
Pharmacotherapeutic group:immunomodulatory agent
ATX code: L03
Pharmacological properties
Pharmacodynamics
Hepon has immunomodulatory and antiviral effects:
- causes production of alpha- and beta- interferons;
- mobilizes and activates macrophages;
- restricts the production of pro-inflammatory cytokines (interleukins 1, 6, 8 and tumor necrosis factor);
- stimulates the production of antibodies to various antigens of infectious nature;
- increases CD4+ T cells and NK cells;
- increases the functional activity of neutrophils and CD8+ T cells, which are key links in the body’s defense against bacteria, viruses and fungi;
- inhibits viral replication.
Because of these pharmacological properties, Hepone increases the resistance of the body against infections caused by viruses, bacteria and fungi. Hepon has an anti-inflammatory effect within 1-2 days after application.
Pharmacokinetics of the drug has not been studied due to its peptide nature.
Indications
As part of combination therapy: treatment of infections of mucous membranes and skin caused by Candida fungi; reducing the intensity of inflammation (redness, swelling, itching, burning, pain) of mucous membranes and skin, dryness of mucous membranes. Prevention of candidiasis of mucous membranes and skin against the background of antibiotic therapy.
Composition
Active ingredient:
threonyl-glutamyl-lysyl-arginyl-arginyl-glutamyl-threonyl-valyl-glutamyl-arginyl-glutamate (Hepone) 1mg, 2 mg
How to take, the dosage
It is used topically, externally.
Before use the drug is dissolved in water for injection (for external use of the drug, i.e. for skin treatment) or in 0.9% sodium chloride solution (for local use of the drug, i.e. for treatment of mucous membranes).
The way of preparing the drug before use:
- Remove the protective part of the aluminum cap from the rubber cap of the vial of the drug. If the drug is in an ampoule, open the ampoule.
- Open the ampoule with the solvent (water for injection). As a solvent can also be used 0.9% sodium chloride solution.
- Place the needle on the disposable syringe (volume 5/10 ml – see Table.
- Pick the solvent into the syringe (the volume of the solvent is given in Table 1).
- Pierce the rubber plug of the vial with the syringe and pour 2 – 2.5 ml of solvent into the vial. If the drug is in an ampoule, pour into the opened ampoule also 2 – 2.5 ml of solvent.
- Without removing the needle, gently oscillating for about 1 minute, completely dissolve the contents of the bottle (ampoule).
- Pick the resulting solution into the syringe with the rest of the solvent. The final volume of the solution in the syringe should correspond to the volume specified in Table 1.
- Eject the syringe with the needle from the bottle (ampoule), with light oscillating movements for about 1 minute, completely mix the solution in the syringe.
- Remove the needle from the syringe.
- Use the syringe as a dispensing device for instillations, dabbing the skin or mucous membranes, or moistening the gauze pads.
Table 1
Hepone, mg | .How to use | Hepone 0.02% solution | Hepone 0.04% solution /strong> | ||||
1 | 2 | 1 | 2 | ||||
Water for injection, ml strong> | externally | – | – | 2.5 | 5 | ||
0.9% sodium chloride solution, ml | locally | 5 | 10 | – | – |
The recommended dose for adults and children 12 years and older is 1-2 mg as a 0.02% solution for topical mucous membrane treatment once daily.
The recommended dose for adults and children 12 years of age and older is 1-2 mg as a 0.04% solution for treatment of the skin once daily.
For the treatment of mucous membrane infections caused by fungi Candida, It is recommended to use Hepone locally by applying it on the affected areas of the mucous membranes (vulva, vagina, urethra) with 0.02% solution, for a course of 3 applications (once a day) with an interval of 1-3 days between applications.
For treatment of skin infections caused by fungi Candida, external application of Hepone by application of 0.04% solution to affected skin areas, for the course of 3 applications (once daily) with intervals of 1-3 days between applications is recommended.
In case of vulvovaginitis, urethritis in women the vulval and vaginal mucosa is treated with 0.02% solution of Hepone as well as lotions on the affected skin adjacent to the vaginal opening with 0.04% solution of Hepone.
In case of urethritis and balanopostitis in men instillation with 0.02% Hepone solution into the urethra and apply lotions to the affected skin areas with 0.04% Hepone solution.
The treatment of mucous membranes and skin is carried out as a course of 3 applications (once a day) with an interval of 1-3 days.
Prevent candidiasis of the mucous membranes against the background of antibiotic therapy. It is recommended to conduct lotions with 0.02 % solution of Hepon during the course of antibiotic treatment. Treatment of mucous membranes is carried out as a course of 3 applications (once a day) at intervals of 1-3 days.
Prevention of candidiasis of the skin against the background of antibiotic therapy: it is recommended to apply 0.04 % gepon solution lotions during antibiotic treatment course. Skin treatment is carried out as a course of 3 applications (once a day) with an interval of 1-3 days.
To reduce the intensity of inflammation and dryness mucous membranes shall be treated with 0.02% Hepon solution. Treatment of mucous membranes is carried out as a course of 3 doses (once a day) with intervals of 1-3 days.
To reduce the intensity of skin inflammation: apply gauze wipes soaked with 0.04% Hepon solution. Treatment of the skin is carried out in a course of 3 applications (once a day) at intervals of 1-3 days.
Special Instructions
The drug does not affect the ability to drive vehicles, moving machinery and engage in other potentially dangerous activities that require high concentration and quick psychomotor reactions.
Synopsis
Lyophilized powder of white color, odorless.
Contraindications
Individual hypersensitivity to Hepone. Childhood under 12 years of age.
Side effects
Not detected. Possible allergic reactions. If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
Symptoms of overdose are not described.
Pregnancy use
Use is possible only if the potential benefit to the mother exceeds the possible harm to the fetus. Hepone is not recommended for use during breastfeeding. If it is necessary to use the drug, breastfeeding should be stopped.
Weight | 0.060 kg |
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Shelf life | 4 years. Do not use after the expiration date. |
Conditions of storage | Store in a light-protected place at a temperature not exceeding 25 ° C. Keep out of reach of children. |
Manufacturer | Immapharma, Russia |
Medication form | lyophilizate |
Brand | Immapharma |
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