Heparin-Acrichin 1000, gel 1000 me/g 50 g

ATX code: C05BA03

Pharmacological properties

Pharmacodynamics

.br>Direct anticoagulant, has anti-inflammatory, antiproliferative, antiedematous and analgesic effects. Reduces platelet aggregation, binds to antithrombin III, preventing the transition of prothrombin to thrombin. Inhibits the activity of thrombin. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of blood. It improves microcirculation and activates tissue exchange, thus accelerating resorption processes of hematomas and thromboses, and finally restores venous patency, clinically it is accompanied by a pronounced analgesic and anti-inflammatory effect.< br>
Pharmacokinetics

A small amount of heparin is absorbed from the skin surface into the systemic bloodstream. The maximum concentration of the active substance in the blood is observed 8 hours after application. Heparin excretion mainly occurs through the kidneys, the half-life is 12 hours.

Indications

– Thrombophlebitis of superficial veins;

– localized infiltrates and swelling of soft tissues;

– tendon and joint injuries;

– bruises of soft tissues and joints.

Pharmacological effect

ATX code: C05BA03

Pharmacological properties

Pharmacodynamics

Direct anticoagulant, has anti-inflammatory, antiproliferative, anti-edematous and analgesic effects. Reduces platelet aggregation, binds to antithrombin III, preventing the transition of prothrombin to thrombin. Inhibits thrombin activity. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of blood. Improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots, ultimately restoring the patency of veins, clinically this is accompanied by a pronounced analgesic and anti-inflammatory effect.

Pharmacokinetics

A small amount of heparin is absorbed from the skin surface into the systemic circulation. The maximum concentration of the active substance in the blood is observed 8 hours after application. Heparin is eliminated primarily through the kidneys, with a half-life of 12 hours.

Special instructions

It is not recommended to use for bleeding, as well as on open wounds, mucous membranes and in the presence of local purulent processes.

Use with extreme caution in cases of increased vascular permeability.

The use of the gel is not recommended for deep venous thrombosis.

Active ingredient

Heparin sodium

Composition

100 g of gel contain:

active substance:

sodium heparin in terms of dry matter – 0.83 g (100,000 IU);

excipients:

methyl parahydroxybenzoate – 0.15 g,

carbomer 940 – 1.25 g,

trometamol – 0.85 g,

ethanol 96% (rectified ethyl alcohol) – 24 g,

lavender oil – 0.02 g,

orange blossom oil (neroli oil) – 0.01 g,

purified water – up to 100 g.

Contraindications

– Hypersensitivity to any of the components of the drug,

– ulcerative-necrotic changes in the skin in the areas where the gel is supposed to be applied,

– traumatic violation of the integrity of the skin,

– decreased blood clotting,

– thrombocytopenia.

Side Effects

– Skin allergic reactions,

– skin hyperemia.

Interaction

It is not recommended to mix with other products for external use. Do not prescribe topically simultaneously with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines.

Concomitant use of the gel with oral anticoagulants may cause prolongation of prothrombin time.

Overdose

Overdose is unlikely due to the low absorption of the gel components. It appears as bleeding. Removed by protamine sulfate (chemical antagonist).

Storage conditions

At temperatures from 15 to 25 °C.

Keep out of the reach of children.

Shelf life

2 years.

Manufacturer

Akrikhin JSC, Russia