Hemase, lyophilizate 5 ths.me 5 pcs

Pharmacological group: fibrinolytic agent.

ATX code: B01AD

Pharmacological properties

Fibrinolytic is a recombinant urokinase-type plasminogen activator. It is a recombinant prourokinase (RPU) and catalyzes the conversion of plasminogen into plasmin, which is capable of lysing fibrin clots. The specificity of RPU action is based on the fact that it preferentially activates fibrin-bound plasminogen, which has a different conformation compared with circulating plasminogen in the bloodstream, into plasmin, and is not sensitive to the specific inhibitors present in plasma in the fibrin clot.

The single-chain RPU molecule under the influence of plasmin is converted into a double-chain molecule, which, unlike the single-chain pro-forma, is significantly more active against fibrin-linked plasminogen. A “chain reaction” of interaction between RPU and fibrin-linked plasminogen is formed, as a result of which the fibrin clot is destroyed. The specific enzymatic activity of Hemase® is 4500 to 5500 ME per ampoule.

Pharmacokinetics

In local periocular administration the maximum concentration of the drug “Hemase®” in the eye tissues is reached by 1-2 hours, the drug concentration gradually decreases, after 12-24 hours the drug is found in trace amounts. Maximum drug concentration is determined in the intraocular structures during intraocular administration. The half-life of the drug is 4-6 hours. Since the dose for topical administration is small (up to 5000 ME), no blood concentrations significant for the systemic action of the drug are produced.

Indications

Hemase® is used in ophthalmology to treat the following pathology:

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

The ability of the drug “Hemase®” to affect the reaction rate when driving motor transport or operating other mechanisms has not been noted.

But depending on the patient’s individual reaction to Gemase® , caution should be exercised when driving and operating machinery during treatment with the drug.

Contraindications

Side effects

Overdose

Pregnancy use

It is contraindicated in pregnancy.