Guttasil, drops 7.5 mg/ml 15 ml

Pharmacotherapeutic group: laxative.
ATX code: A06A B08
Pharmacological properties
Pharmacodynamics
Contact laxative of triarylmethane group, activated in large intestine under the action of bacterial sulfatases; substance released during this – stimulates sensitive nerve endings of intestinal mucosa, increases its motility. Administration of the drug is not accompanied by tenesmias and intestinal spasms.
In case of course treatment Guttasil stimulates the growth and metabolic activity of normal intestinal microflora.

Pharmacokinetics
After oral administration it reaches the large intestine without significant absorption where it is cleaved under the influence of bacterial flora to form the active form – bis-(p-hydroxyphenyl)-pyridyl-2-methane. Laxative effect develops 6-12 hours after intake, the severity of the laxative effect does not correlate with the level of active bis-(p-hydroxyphenyl)-pyridyl-2-methane in blood plasma. It does not undergo hepatic-intestinal recirculation.< br>

Indications

Constipation or cases requiring the facilitation of defecation (hemorrhoids, proctitis, anal fissures, preparation for surgery, instrumental and radiological examinations).

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Pregnancy use

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