Groprinosin, tablets 500 mg 20 pcs

Pharmacotherapeutic group: Immunostimulant
ATX code: J05AX05

Pharmacodynamics

Inosin pranobex is a synthetic purine derivative and is a complex containing inosine and N,N-dimethylamino-2-propanol in a molar ratio of 1:3. It has immunostimulatory activity and nonspecific antiviral action. The effectiveness of the complex is determined by the presence of inosin, the second component increases its availability to lymphocytes.

It restores lymphocyte functions in immunosuppression, increases blastogenesis in monocyte population, stimulates membrane receptor expression on the surface of T-helpers, prevents decrease in lymphocyte activity under glucocorticosteroids influence, normalizes thymidine induction into lymphocytes. Inosin pranobex stimulates the activity of T-lymphocytes and natural killer cells, T-suppressor and T-helper functions, increases immunoglobulin G (Ig G), interferon-gamma, interleukins IL-1 and IL-2 production, decreases anti-inflammatory cytokines – IL-4 and IL-10, potentiates neutrophils, monocytes and macrophages chemotaxis.

The preparation shows antiviral activity in vivo against herpes simplex virus, cytomegalovirus, measles virus, human T-cell lymphoma virus (type III), polioviruses, influenza A and B viruses, human enterocytopathogenic virus (HEV), encephalomyocarditis and horse encephalitis viruses. The mechanism of antiviral action of Pranobex inosine is associated with inhibition of viral RNA and dihydropteroat synthetase involved in replication of some viruses, it enhances the suppressed viral mRNA synthesis of lymphocytes, which is accompanied by reduction of viral RNA synthesis and translation of viral proteins, increases production of alpha and gamma interferons by lymphocytes having antiviral properties. In combination treatment it increases the effect of interferon-alpha, acyclovir and zidovudine.

Pharmacokinetics

After oral administration the drug is well absorbed from the gastrointestinal tract (GIT). Maximum concentration of ingredients in blood plasma is determined after 1-2 hours. It is rapidly metabolized and excreted through the kidneys. It is metabolized similarly to endogenous purine nucleotides with formation of uric acid. N,N-dimethylamino-2-propanol is metabolized to N-oxide, and 4-acetamidobenzoate to o-acylglucuronide. No cumulation of the drug in the body has been detected. The elimination half-life (T1/2) is 3.5 h for N,N-dimethylamino-2-propanol and 50 min for 4-acetamidobenzoate. The drug and its metabolites are eliminated from the body by the kidneys within 24-48 hours.

Indications

Active ingredient

Composition

1 tablet contains:

The active ingredient:inosine pranobex 500 mg.

Associated substances: potato starch, povidone K 25, magnesium stearate.

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use

The use of Groprinosin® during pregnancy and during breastfeeding is contraindicated because the safety of use has not been established.

Similarities