Granisetron concentrates 1 mg/ml 3 ml, 5 pcs.

Granisetron is a selective antagonist of serotonin (5-hydroxytryptamine) 5-NT3 receptors located in the vagus nerve endings and trigger zone of the bottom of the IV ventricle of the brain (has almost no effect on other serotonin receptors) with a pronounced antiemetic effect.

Studies have shown that granisetron has low affinity for other types of receptors, including other types of serotonin receptors and D2-dopamine receptors. It eliminates vomiting resulting from excitation of the parasympathetic nervous system due to serotonin release by enterochromaffin cells.

Granisetron eliminates nausea and vomiting caused by cytotoxic chemotherapy, radiation therapy, and postoperative nausea and vomiting.
It does not affect plasma concentrations of prolactin and aldosterone.

Granisetron blocks potassium hERG channels of the heart, affecting myocardial repolarization. On the electrocardiogram (ECG) indices it is manifested in changes of PR, QRS and especially in prolongation of QT interval.

It has no mutagenic effect in vivo and in vitro.

When administered in high doses for a lifetime it increases the risk of hepatocellular tumors in animals.

Indications

Prevention of nausea and vomiting during cytostatic chemotherapy in adults.

The prevention and treatment of nausea and vomiting during radiation therapy in adults.

Active ingredient

Composition

1 ml of concentrate for preparation of solution for infusion:

The active ingredient:

granisetron hydrochloride 1.42 mg, which corresponds to the content of granisetron 1 mg

Associates:

Sodium chloride – 9 mg,

citric acid monohydrate – 2 mg,

How to take, the dosage

Adults, for oral administration, a single dose of 1 mg; for intravenous infusion, a single dose of 3 mg; for intravenous injection (slowly, not less than 30 seconds), a single dose of 1 mg.

The maximum dose is 9 mg/day.

In children, 40 mcg/kg (but not more than 3 mg) once by IV/ IV drip. For children over 12 years of age, a single dose of 1 mg for oral administration.

The frequency and duration of use are determined individually.

Interaction

Special Instructions

Contraindications

Side effects

Pregnancy use