Gonococcal inactivated vaccine 1ml, 10 pcs.

Enhances specific reactivity of the body (stimulates the production of antibodies with neutralizing, opsonic and protective effects).

Indications

In adults:

• Gonorrhea infection (as part of complex therapy) after unsuccessful antibiotic therapy for sluggish relapses, fresh torpid and chronic forms of the disease, men with complicated and women with ascending gonorrhea (after the acute inflammatory phenomena subside);
• diagnosis of gonorrhea (examination for gonorrhea in patients with chronic diseases of the genitourinary organs, establishment of the curability of gonorrhea).

In children from 3 years of age:

• gonorrheal infection (as part of complex therapy) after unsuccessful antibiotic therapy in sluggish relapses, in fresh torpid and chronic forms of the disease;
• diagnosis of gonorrhea (examination for gonorrhea of patients with chronic diseases of the urogenital organs, establishing the cure of gonorrhea).

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Active ingredient

Gonococcal vaccine for treatment and diagnosis

Composition

1 ml of the drug contains:

Active substance:

Suspension of inactivated gonococcal culture – 10 IU (international units) of standard turbidity sample.

Auxiliary substances:

Sodium chloride – 9 mg;

Phenol – preservative – 2.5 mg;

Water for injection to 1 ml.

How to take, the dosage

The vaccine is injected intramuscularly into the upper outer quadrant of the buttock with pre- and post-injection treatment of the injection site with 70% ethyl alcohol. The injected drug must be at body temperature.

Before filling the syringe the ampoule with the vaccine should be shaken to obtain a homogeneous suspension. The drug in the opened ampoule should not be stored.

In gonorrheal infection:

1. Injections are given to adults at 1-2 day intervals depending on response. The initial dose of the vaccine is 0.3 to 0.4 ml (with complicated gonorrhea, the vaccine should be started at 0.2 to 0.3 ml).
2. At a temperature of 36.9°C or less, the vaccine dose is increased by 0.3 ml each time, the interval of administration is 1 day.
3. If the temperature increases (less than 1.5 ° C from normal), the vaccine dose is increased by 0.15 ml each time, the interval of administration is 2 days.
4. The maximum single dose of vaccine should not exceed 2.0 ml.
5. The vaccine is administered once/day.
6. Treatment duration up to 6 – 8 injections.

Children over 3 years of age are injected at intervals of 1-2 days depending on response.

1. The initial dose of the vaccine is 0.05 to 0.1 ml.
2. At a temperature of no more than 36.9 ° C, the vaccine dose is increased by 0.05 ml each time, the interval of injection is 1 day.
3. If the temperature increases (less than 1.5 ° C from normal), the vaccine dose is increased by 0.025 ml each time, the interval of administration is 2 days.
4. The maximum single dose of the vaccine should not exceed 0.5 ml.
5. The vaccine is administered once/day.
6. Treatment duration up to 6-8 injections.

At diagnosis of gonorrhea:
To establish the cure of gonorrhea, as well as in the examination for gonorrhea of patients with chronic diseases of the genitourinary organs, 0.5 ml of vaccine is administered as a provocation. If the vaccine was used during treatment, double the last therapeutic dose, but no more than 2.0 mL, is administered as a provocation.

Interaction

The simultaneous administration of antibiotic therapy is possible.

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Special Instructions

Possible complications: general reactions – malaise, increase in body temperature to 39.0 ° C for 24 – 48 hours from the time of administration of the vaccine, headache, general weakness; focal reactions – increased discharge, pain in the affected organs, blurred urine; local reactions – pain in the injection area.

In case of complications (allergic reactions of immediate type: anaphylactic shock, Quincke’s edema, urticaria) symptomatic therapy should be administered.
In case of fever (more than 1.5 ° C from normal), general condition deterioration, severe pain in the affected organ the vaccine should be discontinued.

After each injection of the vaccine, the inoculated should be under medical supervision for 30 minutes; emergency and anti-shock therapy must be available at the vaccination sites.

Contraindications

• Tuberculosis (active form);
• .Diseases of the circulatory system (acute rheumatic fever, chronic rheumatic heart disease, coronary heart disease, cerebrovascular disease, diseases of arteries, arterioles and capillaries, pulmonary heart and pulmonary circulation disorders, diseases of veins, lymphatic vessels and lymph nodes, other heart diseases);
• diseases characterized by high blood pressure;
• liver disease (liver fibrosis and cirrhosis, liver sclerosis, toxic liver damage, acute and subacute liver failure, chronic liver failure);
• diseases of the urogenital system (glomerular disease, tubulointerstitial renal disease);
• Renal failure (acute renal failure, renal failure with tubular necrosis, acute renal failure with acute cortical necrosis, acute renal failure with medullary necrosis, other acute renal failure acute renal failure unspecified, chronic renal failure, end-stage renal failure, other manifestations of chronic renal failure, chronic renal failure unspecified, renal failure unspecified);
• personal history of allergy to drugs, medicines, and biological substances;
• menstruation;
• anemia (diet-related, due to enzyme disorders, aplastic and other anemias);
• age under 3 years.

In order to identify contraindications, the doctor (paramedic) on the day of vaccine administration interview and examination of the patient with mandatory thermometry. If an elevated temperature is detected before the first administration of the drug (more than 36.9 ° C) vaccination is not carried out. On subsequent days the vaccine should be administered in accordance with the dosing regimen.

Side effects

General reaction is manifested by malaise, increase in body temperature to 39.0 ° C for 24 – 48 hours after vaccination, headache, general weakness; focal – increased discharge, pain in the affected organs, blurred urine; local – soreness in the injection area.

In case of complications (allergic reactions of immediate type: anaphylactic shock, Quincke’s edema, urticaria) symptomatic therapy should be administered.

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