Glycine Reneval, tablets 100 mg 60 pcs

Pharmacotherapeutic group: metabolic agent.

The ATX code: N06BX

Pharmacological properties

Pharmacodynamics

Glycine is an essential amino acid, a central inhibitory neurotransmitter: improves metabolic processes in brain tissues; has antidepressant and sedative effects; has glycinergic and GABA-ergic, alpha1-adrenoblocking, antioxidant and antitoxic effects; regulates the activity of glutamate (NMDA) receptors, due to which it reduces psychoemotional tension, aggressiveness and conflict; it improves social adaptation and mood; facilitates falling asleep and normalizes sleep; increases mental performance; reduces the severity of vegetative-vascular disorders (including in menopause) and cerebral disorders in ischemic stroke and craniocerebral trauma; reduces the toxic effects of ethanol on the central nervous system.

Pharmacokinetics

Easy penetration into most body fluids and tissues, including the brain, does not cumulate. It is rapidly degraded in the liver by glycinoxidase to water and carbon dioxide.

Indications

Stressful conditions (including psycho-emotional stress);
decreased mental performance;
deviant forms of behavior of children and adolescents;
various functional and organic diseases of the nervous system, accompanied by increased excitability, emotional instability, decreased mental performance and sleep disturbances: neuroses, neurosis-like conditions, vegetative-vascular dystonia, consequences of neuroinfections and traumatic brain injury, perinatal and other forms of encephalopathies (including alcoholic origin);
ischemic stroke.

In narcology, glycine is used as a drug that increases mental performance and reduces psycho-emotional stress during the period of remission in cases of encephalopathy, organic lesions of the central and peripheral nervous system.

Pharmacological effect

Pharmacotherapeutic group: metabolic agent.

ATX code: N06BX

Pharmacological properties

Pharmacodynamics

Glycine is a non-essential amino acid, a central inhibitory neurotransmitter: improves metabolic processes in brain tissue; has an antidepressant and sedative effect; has glycinergic and GABAergic, alpha1-adrenergic blocking, antioxidant and antitoxic effects; regulates the activity of glutamate (NMDA) receptors, thereby reducing psycho-emotional stress, aggressiveness and conflict; improves social adaptation and mood; makes it easier to fall asleep and normalizes sleep; increases mental performance; reduces the severity of vegetative-
vascular disorders (including during menopause) and cerebral disorders in ischemic stroke and traumatic brain injury; reduces the toxic effect of ethanol on the central nervous system.

Pharmacokinetics

Easily penetrates into most biological fluids and tissues of the body, including the brain, and does not accumulate. It is quickly destroyed in the liver by glycine oxidase to water and carbon dioxide.

Special instructions

In patients with a tendency to arterial hypotension, the prescription is made in smaller doses and with blood pressure control. If blood pressure drops below the usual level, glycine intake is stopped.

Impact on the ability to drive vehicles and machinery

When taking the drug, caution should be exercised when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Glycine

Composition

Active ingredient:

Glycine – 100 mg

Excipients:

methylcellulose – 1 mg

magnesium stearate – 1 mg

Pregnancy

The drug is not recommended for use during pregnancy and breastfeeding, due to the lack of sufficient data on the safety of the drug during this period.

Contraindications

Hypersensitivity to glycine and/or other components of the drug.

With caution

Arterial hypotension.

Side Effects

Allergic reactions, drowsiness.

Interaction

Reduces the severity of side effects of antipsychotic drugs (neuroleptics), anxiolytics, antidepressants, sleeping pills and anticonvulsants.

Overdose

Cases of overdose have not been described.

Storage conditions

In a pack at a temperature not exceeding 25 °C.
Keep out of the reach of children.

Shelf life

3 years.
Do not use after expiration date.

Manufacturer

Update of PFC JSC, Russia