Glutargin alcocline, tablets 1 g 10 pcs

Glutargin is a salt of arginine and glutamic acid. < br>

In alcohol intoxication it stimulates alcohol utilization in monooxygenase system of the liver, prevents inhibition of the key enzyme of ethanol utilization – alcohol dehydrogenase; accelerates inactivation and excretion of toxic products of ethanol metabolism as a result of increased formation and oxidation of succinic acid; reduces depressant effects of alcohol on CNS due to neurotransmitter properties of excitatory glutamic acid.

Because of these properties Glutargin exhibits antitoxic and sobering effects.

Glutargin also possesses hypoammonemic and hepatoprotective properties due to activation of ammonia deactivation in the body, antioxidant, antihypoxic and membrane stabilizing effects and positive influence on energy supply processes in hepatocytes.

Glutargin has no embryotoxic, gonadotoxic, mutagenic and teratogenic effects and does not cause allergic and immunotoxic reactions.

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Indications

Prevention of intoxication and hepatoxic effects of alcohol.

Treatment of acute alcohol intoxication and moderate severity, as well as as part of complex therapy for post-intoxication disorders after acute severe alcohol poisoning.

Pharmacological effect

Glutargin is a salt of arginine and glutamic acid.

In case of alcohol intoxication, it stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents inhibition of the key enzyme for the utilization of ethanol – alcohol dehydrogenase; accelerates the inactivation and elimination of toxic products of ethanol metabolism as a result of increased formation and oxidation of succinic acid; reduces the inhibitory effect of alcohol on the central nervous system due to the neurotransmitter properties of stimulating glutamic acid.

Thanks to these properties, Glutargin exhibits antitoxic and sobering effects.

Glutargin also has hypoammonemic and hepatoprotective properties due to the activation of ammonia neutralization processes in the body, antioxidant, antihypoxic and membrane stabilizing effects, and has a positive effect on energy supply processes in hepatocytes.

Glutargin does not have embryotoxic, gonadotoxic, mutagenic or teratogenic effects, does not cause allergic or immunotoxic reactions.

Special instructions

When prescribing to patients with dysfunction of the endocrine glands, it should be taken into account that the drug may slightly increase the secretion of insulin and growth hormones, which does not require adjustment of drug therapy in patients with diabetes mellitus and/or acromegaly

Effect of the drug on the ability to drive vehicles

The drug does not affect the ability to drive vehicles

Active ingredient

Arginine glutamate

Composition

Pills.

Active ingredient:

arginine glutamate (calculated as 100% substance) 1.0 g.

Excipient:

microcrystalline cellulose (MCC 101) 0.110 g,

crospovidone 0.020 g,

calcium stearate 0.010 g.

Contraindications

– hypersensitivity to the components of the drug

– children under 18 years of age

– period of pregnancy and breastfeeding

With caution

– feverish condition

– increased excitability

– severe impairment of the filtration (nitrogen excretion) function of the kidneys (creatinine clearance 30 ml/min).

Side Effects

Rarely, feelings of mild discomfort in the epigastric region and nausea may be observed immediately after using the drug, which go away on their own.

Overdose

Symptoms: nausea, vomiting, pain in the chest, discomfort in the epigastric region, insomnia, transient short-term decrease in blood pressure, atrioventricular block, allergic reactions.

Treatment: symptomatic, if necessary, taking antihistamines, in severe cases – intravenous administration of glucocorticosteroids.

Storage conditions

Store in original packaging at a temperature not exceeding 25°C. Keep out of the reach of children.

Manufacturer

Health, Ukraine