Glutargin alcocline, 1 g 3 g 2 pcs

Pharmgroup:

Hypoammonemic drug.

Pharmaceutical action:

Glutargin alcoclin is a compound of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralization and excretion of highly toxic metabolite of nitrogenous substances metabolite – ammonia. It has hepatoprotective effect with antioxidant, antihypoxic and membrane stabilizing activity, has a positive effect on energy supply processes in hepatocytes.

In case of alcohol intoxication Glutargin Alcocline stimulates alcohol utilization in monooxygenase system of the liver and prevents inhibition of the key enzyme of ethanol utilization – alcohol dehydrogenase; it accelerates inactivation and excretion of toxic products of ethanol metabolism as a result of increased formation and oxidation of succinic acid; it reduces the depressant effect of alcohol on CNS due to neurotransmitter properties of excitatory glutamic acid.

Glutargin alcocline has no embryotoxic, gonadotoxic and mutagenic effects, does not cause allergic and immunotoxic reactions.

Indications

Prevention of intoxication and hepatoxic effects of alcohol.

The treatment of acute alcohol intoxication and moderate degree of severity, as well as in the complex therapy of postintoxication disorders after severe acute alcohol poisoning.

Active ingredient

Composition

Powder for the preparation of a solution for oral administration.

Active ingredient:

arginine glutamate (in terms of 100% substance) 1.0 g.

Auxiliary Substance:

Glycine 0.50 g,

Mannitol (E421) 0.79 G,

Citric acid (aqueous-free) 0.60 g,

aspartame (E951) 0.06 g,

Lemon flavoring 0.05 g.

How to take, the dosage

The drug is administered to adults orally, regardless of meals, pre-dissolve the bag in ¼ – ½ cup of water.

To prevent intoxication and hepatotoxic effects of alcohol 2 packets (2g arginine glutamate) are prescribed 1-2 hours before alcohol intake or 1 packet (1g arginine glutamate) 1 hour before alcohol intake and 1 packet (1g arginine glutamate) within 0.5 hours after alcohol intake.

To treat acute alcohol intoxication of mild and moderate severity, 1 sachet 4 times a day with an interval of 1-2.5 hours, in the next 2-3 days – 1 sachet 2 times a day.

In case of severe alcohol intoxication, after a course of intravenous administration of Glutargin Alcoclin, 1 sachet 2 times a day for 20 days as part of complex therapy.

Special Instructions

When prescribing to patients with endocrine dysfunction, it should be noted that the drug may slightly increase insulin and growth hormone secretion, which does not require correction of drug therapy in patients with diabetes and/or acromegaly./p>

The effect of the drug on driving ability

The drug does not affect driving ability

Contraindications

– hypersensitivity to the components of the drug

– childhood under 18 years

– pregnancy and lactation

– phenylketonuria, as the drug contains aspartame

With caution

– febrile condition

– hypersensitivity

– severe impairment of filtration (nitrogen-excreting) renal function (creatinine clearance 30 ml/min)

Side effects

Slight discomfort in the epigastric region and nausea immediately after using the drug may rarely occur, but it clears on its own.

Overdose

Symptoms: nausea, vomiting, pain in the chest area, discomfort in the epigastric region, insomnia, transient transient decrease of blood pressure, atrioventricular block, allergic reactions.

Treatment: symptomatic, if necessary antihistamines, in severe cases – intravenous administration of glucocorticosteroids.