Glucose, 5% 250 ml

Pharmgroup:

Feeding carbohydrate agent.

Pharmic Action:

Participates in various metabolic processes in the body.

The infusion of dextrose solutions partially replenishes the water deficit. On entering the tissues dextrose is phosphorylated into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism.

The 5% solution of dextrose is isotonic to blood plasma. Hypertonic solutions (10%, 20%, 40%) increase osmotic blood pressure, increase diuresis. The theoretical osmolarity of 10% dextrose is 555 mOsm/L, 20% – 1110 mOsm/L.

Pharmacokinetics:

Is fully absorbed by the body, is not excreted by the kidneys (the appearance in the urine is a pathological sign).

Indications

Hypoglycemia, carbohydrate deficiency, toxic infection, intoxication due to liver diseases (hepatitis, liver dystrophy and atrophy, including liver failure), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.

As a component of various blood replacement and anti-shock fluids; for the preparation of drug solutions for intravenous administration.

Pharmacological effect

Pharmaceutical group:

nutritional carbohydrate remedy.

Pharmaceutical action:

Participates in various metabolic processes in the body.

Infusion of dextrose solutions partially compensates for the water deficiency. Dextrose, entering the tissues, is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism.

A 5% dextrose solution is isotonic to blood plasma. Hypertonic solutions (10%, 20%, 40%) increase the osmotic pressure of the blood and increase diuresis. The theoretical osmolarity of 10% dextrose is 555 mOsm/l, 20% is 1110 mOsm/l.

Pharmacokinetics:

It is completely absorbed by the body and is not excreted by the kidneys (appearance in urine is a pathological sign).

Special instructions

For more complete and rapid absorption of dextrose, you can administer 4-5 units of short-acting insulin subcutaneously, at the rate of 1 unit of short-acting insulin per 4-5 g of dextrose.

Active ingredient

Dextrose

Contraindications

Hypersensitivity, hyperglycemia, hyperlacticacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten cerebral and pulmonary edema; cerebral edema, pulmonary edema, acute left ventricular failure, hyperosmolar coma, childhood (for solutions over 20-25%).

With caution. Decompensated CHF, chronic renal failure (oligo-, anuria), hyponatremia, diabetes mellitus.

Side Effects

Hypervolemia, acute left ventricular failure.

At the injection site – the development of infection, thrombophlebitis.

Interaction

When combined with other drugs, it is necessary to control pharmaceutical compatibility, incl. visually.

Overdose

Symptoms: hyperglycemia, glycosuria, hyperglycemic hyperosmolar coma, hyperhydration, water-electrolyte imbalance, increased liponeogenesis with increased production of CO2, which leads to a sharp increase in minute tidal volume, and, as a consequence, respiratory rate; fatty infiltration of the liver.

Treatment: stop administering glucose, administer insulin, symptomatic therapy.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 2-8°C.

Shelf life

3 years

Manufacturer

Medpolymer, Russia