Glucose, 400 mg/ml 10 m 10 pcs

How to take, the dosage

The concentration and dose of the administered solution depend on the age, body weight and clinical condition of the patient.

The drug should be administered under regular medical supervision.

Clinical and biological parameters, in particular blood glucose concentration and water-salt balance should be carefully monitored.

Adults and adolescents aged 15 years and older: maximum daily dose is 15 ml per kg body weight per day, which corresponds to 6 g of glucose per kg body weight per day. Maximal infusion rate is 0.62 ml per kg of body weight per hour, which corresponds to 0.25 g of glucose per kg of body weight per hour. For a patient with the body mass of 70 kg the maximal infusion rate is 43 ml per hour (glucose – 17,5 g per hour).

Children: maximum daily dose: Premature infants – 18 g dextrose per kg body weight, or 45 ml per kg body weight; preterm infants – 15 g dextrose per kg body weight, or 37.5 ml per kg body weight; 1-2 years – 15 g per kg body weight/37.5 ml per kg body weight; 3-5 years – 12 g per kg body weight/30 ml per kg body weight; 6-10 years – 10 g per kg body weight/to 25 ml per kg body weight; 11-14 years – 8 g per kg body weight/20 ml per kg body weight. When administered to newborn children the high osmolarity of the solution should be taken into account.

Elderly patients: in general the doses recommended for adults are used, but caution should be exercised when determining the amount of liquid administered and the dose of dextrose in patients with cardiac or renal insufficiency.

Patients with reduced glucose metabolism (e.g., in the early postoperative or posttraumatic period, with hypoxia, or organ failure): blood glucose concentrations should be carefully monitored. To avoid hyperglycemia the level of possible glucose oxidation should not be exceeded.

For more complete assimilation of dextrose administered in large doses, short-acting insulin is prescribed simultaneously with it at the rate of 1 IU of insulin per 4-5 g of dextrose. Patients with diabetes are administered dextrose under control of its concentration in blood and urine.

Maximum volumes within the recommended doses should be administered within 24 hours to avoid hemodelution.

The maximum infusion rate should not exceed the patient’s glucose utilization threshold, as this may lead to hyperglycemia.

Depending on the clinical condition of the patient, the infusion rate may be reduced to reduce the risk of osmotic diuresis

Interaction

Concomitant use of catecholamines and steroids reduces glucose absorption. When mixing with other drugs it is necessary to visually monitor them for incompatibility.

In the absence of compatibility studies the drug should not be mixed with other drugs.

Before adding any drug, make sure that it is soluble and stable in water in the pH range of the drug.

Once a compatible drug is added to the drug, the resulting solution should be administered immediately.

Medicines with known incompatibilities should not be used.

Dextrose solutions should not be administered through the same infusion system as for hemotransfusion, risk of hemolysis and thrombosis is possible.

Special Instructions

The glucose solution should not be administered quickly or for long periods of time. If chills occur during the infusion of the solution, the infusion should be stopped immediately. To prevent thrombophlebitis, it should be injected slowly through large veins.

For more complete and rapid absorption of dextrose, 4-5 IU of short-acting insulin may be given by injection, at a rate of 1 IU of short-acting insulin per 4-5 g of dextrose.

Patient monitoring should include regular monitoring of blood glucose concentrations, water balance, plasma ejectrolyte concentrations-potassium in particular-and acid-base balance.

Prescribing glucose solution in the acute period of severe craniocerebral trauma and acute stroke is not recommended, since the drug may increase damage to brain structures and worsen the course of the disease (except in case of correction of hypoglycemia).

In cases of hypokalemia, administration of glucose solution should be combined with correction of potassium deficiency (because of the risk of increasing hypokalemia).

In hypotonic dehydration, the use of the drug is indicated simultaneously with the administration of hypertonic saline solutions.

In diabetic patients dextrose is administered under control of blood and urine sugar content.

In patients with renal insufficiency, decompensated heart failure, hyponatremia, special caution is required when administering glucose, the parameters of central hemodynamics should be controlled.

Pediatric use

In newborns and premature infants, administration of 40% glucose solution in doses greater than 1 ml/kg by weight is not recommended because of the high risk of encephalopathy caused by administration of the hypertonic solution.

Pregnancy and lactation

The use during breastfeeding, taking into account the excess of the estimated benefit to the mother and the potential risk to the child, provided that the electrolyte and fluid balance is controlled and within physiological limits. It is possible to use with caution, if necessary, in pregnant women with reduced glucose tolerance, under control of blood glucose levels.

Particulars of the effect of the drug on the ability to drive a vehicle or potentially dangerous machinery.

The drug does not affect the ability to drive vehicles, operate machinery as well as engage in potentially hazardous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity to the components of the drug, hyperglycemia, hyperlactatemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten cerebral and pulmonary edema; cerebral edema, pulmonary edema, acute left ventricular failure, hyperosmolar coma, childhood age (without dilution), decompensated diabetes, dextrose intolerance, including metabolic stress.

With caution

Decompensated chronic heart failure, chronic renal failure (oligo-, anuria), hyponatremia, diabetes mellitus.

Side effects

– impaired ion balance

– hyperglycemia

– acute left ventricular failure

– fever

– hyperglycemic hyperosmolar coma

– impaired water-electrolyte balance

– When increasing the rate of administration – osmotic diuresis with loss of water, electrolytes and development of hyperosmolar coma

Injection site – development of infection, sometimes – thrombophlebitis

In repeated administration of the solution the functional state of the liver and exhaustion of the insular apparatus of the pancreas are possible.

.

Overdose

Symptoms: hyperglycemia, glucosuria, hyperglycemic, hyperosmolar coma, hyperhydration, disruption of water-electrolyte balance, fatty liver infiltration, acute left ventricular failure, ion balance disorders.

Treatment: stop glucose administration, inject short-acting insulin, symptomatic therapy

Pregnancy use

The drug safety and efficacy during pregnancy and breastfeeding has not been established.

Use of the drug during pregnancy and breastfeeding is possible only by doctor’s prescription if the expected benefits to the mother exceed the potential risk to the fetus or child. 40% glucose solution during pregnancy and during breastfeeding may be used only if supervised by a physician.

Similarities

Dextrose, Glucose Solution, Glucose