Glucose, 10% 200 ml

Glucose solution participates in various metabolic processes in the body, enhances redox processes in the body, improves antitoxic function of the liver, enhances the contractile activity of the heart muscle. Infusion of dextrose solutions partially replenishes water deficit. Dextrose entering the tissues is phosphorylated into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism.

The 5% solution of dextrose has a detoxifying, metabolic effect and is a source of a valuable easily digestible nutrient. When dextrose is metabolized in the tissues, a significant amount of energy is released, necessary for the vital activity of the body.

The 5% dextrose solution is isotonic. The energetic value of 5% solution of dextrose is 200 kcal/l, the approximate osmolarity of 5% solution is 278 mOsm/l, and that of 10% solution is 555 mOsm/l

The 5% solution of dextrose isotonic.

Pharmacokinetics

Dextrose is metabolized through pyruvate and lactate to carbon dioxide and water with release of energy.

It is completely absorbed by the body, but is not excreted by the kidneys (the appearance in the urine is a pathological sign).

Additional pharmacokinetic properties are determined by the drugs added

Indications

Hypertensive dehydration;
parenteral nutrition;
study of kidney function in dehydrated patients (10% solution).

Pharmacological effect

Glucose solution is involved in various metabolic processes in the body, enhances redox processes in the body, improves the antitoxic function of the liver, and enhances the contractile activity of the heart muscle. Infusion of dextrose solutions partially compensate for the water deficiency. Dextrose, entering the tissues, is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism.

A 5% dextrose solution has a detoxifying, metabolic effect and is a source of valuable, easily digestible nutrients. When dextrose is metabolized in tissues, a significant amount of energy is released, which is necessary for the functioning of the body.

5% dextrose solution is isotonic. The energy value of a 5% dextrose solution is 200 kcal/l, the approximate osmolarity of a 5% solution is 278 mOsm/l, 10% solution is 555 mOsm/l

Pharmacokinetics

Dextrose is metabolized through pyruvate and lactate to carbon dioxide and water, releasing energy.

It is completely absorbed by the body and is not excreted by the kidneys (appearance in urine is a pathological sign).

Additional pharmacokinetic properties are determined by the added drugs

Special instructions

For more complete and rapid absorption of dextrose, you can administer 4-5 units of short-acting insulin subcutaneously, at the rate of 1 unit of short-acting insulin per 4-5 g of dextrose.

Active ingredient

Dextrose

Composition

Active ingredient:

dextrose monohydrate 10 g.

Contraindications

Hypotonic dehydration.

Side Effects

Hypervolemia, acute left ventricular failure. At the injection site – the development of infection, thrombophlebitis.

Interaction

When combined with other drugs, it is necessary to control pharmaceutical compatibility, incl. visually.

Overdose

Symptoms: hyperglycemia, glycosuria, hyperglycemic hyperosmolar coma, hyperhydration, water-electrolyte imbalance, increased liponeogenesis with increased production of CO2, which leads to a sharp increase in minute tidal volume, and, as a consequence, respiratory rate; fatty infiltration of the liver.

Treatment: stop administering glucose, administer insulin, symptomatic therapy.

Storage conditions

In a place protected from light, at a temperature of 5–30 °C.

Shelf life

3 years

Manufacturer

Eskom NPK, Russia