Glucose-Solofarm Polyflac Domus, 5% 400 ml

Interaction

When combining with other drugs it is necessary to control pharmaceutical compatibility, including visual.

When combined with sodium chloride solution has an additive effect on the osmolarity of the solution.

In view of the fact that glucose is a fairly strong oxidizing agent, it should not be administered in the same syringe with hexamethylantetramine.

The glucose solution should not be mixed in the same syringe with general anesthetics and hypnotics (their activity is reduced), alkaloid solutions (they decompose).

Glucose weakens the effect of analgesics, adrenomimetics, inactivates streptomycin, reduces the effectiveness of nystatin.

In order to improve glucose absorption in normoglycemic states, it is advisable to combine the drug with administration of 4-8 units of short-acting insulin.

Directions for use

It is administered only intravenously, by jetting 10-50 ml once. Maximum daily dose for adults is 250 ml.

Special Instructions

The glucose solution should not be administered quickly or for long periods of time. If chills occur during the infusion of the solution, the infusion should be stopped immediately. To prevent thrombophlebitis, it should be injected slowly through large veins.

For more complete and rapid absorption of dextrose, 4-5 IU of short-acting insulin may be given by injection, at a rate of 1 IU of short-acting insulin per 4-5 g of dextrose.

Patient monitoring should include regular monitoring of blood glucose concentrations, water balance, plasma ejectrolyte concentrations-potassium in particular-and acid-base balance.

Prescribing glucose solution in the acute period of severe craniocerebral trauma and acute stroke is not recommended, since the drug may increase damage to brain structures and worsen the course of the disease (except in case of correction of hypoglycemia).

In cases of hypokalemia, administration of glucose solution should be combined with correction of potassium deficiency (because of the risk of increasing hypokalemia).

In hypotonic dehydration, the use of the drug is indicated simultaneously with the administration of hypertonic saline solutions.

In diabetic patients dextrose is administered under control of blood and urine sugar content.

In patients with renal insufficiency, decompensated heart failure, hyponatremia, special caution is required when administering glucose, the parameters of central hemodynamics should be controlled.

Pediatric use

In newborns and premature infants, administration of 40% glucose solution in doses greater than 1 ml/kg by weight is not recommended because of the high risk of encephalopathy caused by administration of the hypertonic solution.

Pregnancy and lactation

The use during breastfeeding, taking into account the excess of the estimated benefit to the mother and the potential risk to the child, provided that the electrolyte and fluid balance is controlled and within physiological limits. It is possible to use with caution, if necessary, in pregnant women with reduced glucose tolerance, under control of blood glucose levels.

Particulars of the effect of the drug on the ability to drive a vehicle or potentially dangerous machinery.

The drug does not affect the ability to drive vehicles, operate machinery as well as to engage in potentially hazardous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

– hypersensitivity to the drug

– hyperglycemia

– hyperlactacidemia

p> – hyperhydration

– hyperosmolar coma

– brain edema

– pulmonary edema

– acute left ventricular failure

– postoperative impaired glucose utilization

– circulatory disturbances threatening cerebral and pulmonary edema

– decompensated diabetes mellitus

With caution:

Decompensated chronic heart failure, chronic renal failure (oligo-, anuria), hyponatremia, diabetes mellitus

Side effects

– impaired ion balance

– hyperglycemia

– acute left ventricular failure

– fever

– hyperglycemic hyperosmolar coma

– impaired water-electrolyte balance

– When increasing the rate of administration – osmotic diuresis with loss of water, electrolytes and development of hyperosmolar coma

Injection site – development of infection, sometimes thrombophlebitis

If the solution is repeatedly administered, the functional state of the liver and exhaustion of the insular apparatus of the pancreas are possible.

Overdose

Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disruption of water-electrolyte balance, increased liponeogenesis with increased production of CO2, which leads to a sharp increase in minute respiratory volume and, consequently, respiratory rate; fatty liver infiltration.

Treatment: stop glucose administration, administer short-acting insulin, symptomatic therapy.

Similarities

Dextrose, Glucose Solution, Glucose