Glevo, 500 mg 10 pcs

Glevo is an antibacterial drug of the group of fluoroquinolones of broad spectrum.

Levofloxacin blocks DNA-hymerase (topoisomerase II) and topoisomerase IV, disrupts superspiralization and cross-linking of DNA breaks, inhibits DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and membranes of microorganisms.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

Active ingredient

Composition

film-coated tablets

1 tablet contains levofloxacin (in hemihydrate form) 500 mg

How to take, the dosage

Glevo is taken orally, once or twice a day. The average dose is 250 or 500 mg per day.

Interaction

In concomitant use levofloxacin increases T1/2 of cyclosporine.

The action of the drug is reduced by drugs that inhibit intestinal motility, sucralfate, aluminum/magnesium-containing antacids and iron salts (a break of at least 2 hours between doses is necessary).

Concomitant use of Glevo with NSAIDs, theophylline increases seizure activity.

The simultaneous use of Glevo with GCS increases the risk of tendon rupture.

Cimetidine and drugs that block tubular secretion slow the excretion of levofloxacin.

The simultaneous use of hypoglycemic drugs with levofloxacin may result in hypo- and hyperglycemia.

That is why strict control of blood glucose levels is necessary.

Special Instructions

At the time of treatment, sunlight and artificial UV exposure should be avoided to avoid skin damage (photosensitization).

Contraindications

Side effects

Digestive system disorders: nausea, vomiting, diarrhea (including blood), digestive disorders, decreased appetite, abdominal pain, pseudomembranous enterocolitis, increased liver transaminases activity, hyperbilirubinemia, hepatitis, dysbacteriosis.

Cardiovascular system disorders: decreased BP, vascular collapse, tachycardia, prolongation of QT interval; extremely rarely – atrial fibrillation.

Endocrine system disorders: hypoglycemia (increased appetite, increased sweating, trembling, nervousness).

CNS and peripheral nervous system disorders: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, motor disorders, epileptic seizures (in predisposed patients).

Sensory organs: disorders of vision, hearing, smell, taste and tactile sensitivity.

Overdose

Symptoms:nausea, gastrointestinal mucosal erosions, prolonged QT interval, confusion, dizziness, seizures.

Treatment:Symptomatic therapy is administered, dialysis is not effective.

Similarities