Gemtranix 50 mg/ml 5 ml, 10 pcs.

Pharmacodynamics: Tranexamic acid is an antifibrinolytic agent specifically inhibiting the activation of profibrinolysin (plasminogen) and its conversion into fibrinolysin (plasmin). It has local and systemic hemostatic action in bleeding associated with increased fibrinolysis. In in vitro studies tranexamic acid in high concentrations reduced complement activity. Pharmacokinetics: Absorption Peak plasma concentration after intravenous administration (500 mg) is reached immediately and then the concentration gradually decreases. Distribution Binding to plasma proteins (plasminogen) of tranexamic acid is approximately 3%. The initial volume of distribution is approximately 9-12 liters. Tranexamic acid passes through the placenta. After an intravenous injection of 10 mg/kg in pregnant women, the concentration of tranexamic acid in serum is in the range of 10-53 µg/ml, while that in umbilical cord blood is in the range of 4-31 µg/ml. Tranexamic acid penetrates rapidly into the joint fluid and synovial membranes, with a delay into the cerebrospinal fluid. After intravenous injection of 10 mg/kg in patients undergoing knee surgery, the concentrations in synovial fluids were the same as in the corresponding serum samples. Tranexamic acid concentrations in breast milk were a hundredth of those observed in blood and a tenth of those observed in cerebrospinal and intraocular fluids. Tranexamic acid has been found in semen, where it inhibits fibrinolytic activity but does not affect sperm migration. Excretion Tranexamic acid is excreted with urine via glomerular filtration unchanged. Total renal clearance is equal to total plasma clearance (110-116 ml/min). The excretion of tranexamic acid is about 90% during the first 24 hours after intravenous administration of 10 mg/kg body weight. The elimination half-life (T1/2) is about 3 hours. Special groups Patients with renal insufficiency have increased plasma concentrations of tranexamic acid.

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