Gastal, mint tablets 48 pcs.

Gastric and duodenal ulcer, Gastritis, Chronic pancreatitis, Heartburn, Sour belching, Reflux esophagitis

• Dyspeptic phenomena such as discomfort or pain in the epigastrium, heartburn, sour belching after errors in diet, excessive use of ethanol, coffee, nicotine, etc.
• dyspeptic phenomena, such as discomfort or pain in the epigastrium, heartburn, sour belching (and their prevention), arising from the use of certain drugs (nonsteroidal anti-inflammatory drugs, glucocorticosteroids, etc.).
• conditions accompanied by increased acid generation: gastric ulcer, gastritis, reflux esophagitis; hernia of the esophageal orifice of the diaphragm.

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How to take, the dosage

Over the mouth, gradually crumbling.

Adults and children over 12 years of age with a body weight of at least 50 kg

Taking 1-2 tablets 4-6 times a day about 1 hour after meals and before going to bed, but not more than 8 tablets a day. The duration of use is not more than 2 weeks.

Similar doses are recommended for the treatment of heartburn regardless of meals.

Adults and children over 12 years of age with body weight less than 50 kg, children aged 6 to 12 years

The dose is half of the recommended dose for adults and children over 12 years of age with body weight at least 50 kg. The duration of use is not more than 2 weeks.

Patients with CKD

Dose adjustment is not required. The duration of treatment is not more than 2 weeks.

Interaction

When used concomitantly, the drug Gastal® increases the activity of levodopa and nalidixic acid, reduces and delays absorption of quinolones, isoniazid, naproxen, iron drugs, indomethacin, aminazine, beta-adrenal blockers, diflunisal, H2-histamine receptor blockers, fat-soluble vitamins, indirect anticoagulants, barbiturates.

In interaction with metal ions from antacids, tetracyclines form insoluble chelate complexes; as a result of this interaction, absorption of tetracyclines is reduced by more than 90%. Simultaneous administration of these drugs is not possible. If combined administration is necessary, tetracycline should be taken at least 2 hours before taking the antacid.

In the presence of aluminum and magnesium hydroxides contained in the antacid, absorption of ciprofloxacin and ofloxacin is reduced by 50-90%.

The bioavailability of captopril is significantly reduced in the presence of antacids, and the combined use of antacids and metoprolol leads to decreased plasma concentrations of metoprolol.

The concomitant use of high doses of antacids may reduce the absorption of ranitidine by 10-33%.

The use of antacids does not affect the bioavailability of amoxicillin, cephalexin and the combination of amoxicillin and clavulanic acid, but may significantly reduce the absorption of doxycycline from the GI tract.

Elevated urinary pH on antacid therapy may increase tubular reabsorption of basic (alkaline) drugs and decrease reabsorption of acidic compounds. Antacids may decrease and slow absorption of salicylates, including acetylsalicylic acid, and by increasing urinary pH may promote faster urinary excretion of salicylates from the body, with an accompanying 30-70% decrease in their serum concentrations.

The absorption of cardiac glycosides, including digoxin and digitoxin, when used concomitantly with antacids is not significantly reduced.

M-cholinoblockers, by slowing gastric motility, increase the duration of action of the drug Gastal®.

In order to prevent possible interaction of the drug Gastal® with other drugs it is recommended to take it 1 hour before or 1 hour after their administration.

Special Instructions

Contraindications

With caution when using the drug in chronic renal failure, pregnancy and lactation, in adults and children older than 12 years of age with a body weight less than 50 kg, in children aged 6 to 12 years, elderly patients.

Side effects

When using the drug in the recommended doses, adverse reactions are rare (at least 0.01%, but less than 0.1%): nausea, constipation, diarrhea, changes in taste sensation. In exceptional cases allergic reactions are possible.

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Overdose

Pregnancy use

The drug Gastal is not excreted with breast milk.

When using during pregnancy and during breastfeeding it is necessary to evaluate the ratio of benefit to the mother and risk to the fetus and the baby.