Furosemide, tablets 40 mg 50 pcs

How to take, the dosage

In adults with edema, 40 mg once daily (up to 80-120 mg/day); after increasing diuresis, the dose is reduced to a maintenance dose of 40 mg every other day.

In children at a rate of 1-2 mg/kg/day.

Interaction

Concomitant use of Furosemide with cardiac glycosides increases the risk of glycoside intoxication, and when combined with GCS, the risk of hypokalemia.

Special Instructions

Caution is exercised when the drug is prescribed in severe cardiovascular insufficiency, during prolonged therapy with cardiac glycosides, as well as in elderly patients with severe atherosclerosis. Serious water-electrolyte balance disorders should be compensated before the beginning of treatment.

Contraindications

Hypersensitivity, anuria, uremia, hepatic coma, mechanical obstruction of the urinary tract, dyselectrolymia.

Side effects

Cardiovascular system disorders: decreased BP, orthostatic hypotension, collapse, tachycardia, arrhythmias, decreased blood circulation.

CNS and peripheral nervous system disorders: dizziness, headache, myasthenia gravis, cramps of the calves (tetany), paresthesias, apathy, adynamia, weakness, drowsiness, somnolence, confusion.

Sensory organs: visual and hearing disorders.

Digestive system disorders: decreased appetite, dry mouth, thirst, nausea, vomiting, constipation or diarrhea, cholestatic jaundice, pancreatitis (exacerbation).

Urogenital system disorders: oliguria, acute urinary retention (in patients with prostatic hypertrophy), interstitial nephritis, hematuria, reduced potency.

Hematopoietic system disorders: leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia.

Water-electrolyte metabolism: hypovolemia, dehydration (risk of thrombosis and thromboembolism), hypokalemia, hyponatremia, hypochloremia, hypocalcemia, hypomagnesemia, metabolic alkalosis.

Metabolism disorders: hypovolemia, hypokalemia, hyponatremia, hypochloremia, hypokalemic metabolic alkalosis (arterial hypotension, dizziness, dry mouth, thirst, arrhythmia, muscle weakness, seizures as a consequence of these disorders), hyperuricemia (with possible aggravation of gout), hyperglycemia.

Allergic reactions: purpura, urticaria, exfoliative dermatitis, erythema multiforme, vasculitis, necrotizing angiitis, skin itching, chills, fever, photosensitization, anaphylactic shock.

Others: when administered intravenously (additionally) – thrombophlebitis, calcification of the kidneys in premature infants.

Overdose

Symptoms: BP decrease, collapse, shock, hypovolemia, dehydration, hemoconcentration, arrhythmias, acute renal failure with anuria, thrombosis, thromboembolism, drowsiness, confusion, flaccid paralysis, apathy.

Treatment: correction of the water-salt balance and acid-base balance (CB), replenishment of circulating blood volume, symptomatic treatment.

There is no specific antidote.