Furosemide, tablets 40 mg 50 pcs

Furosemide is a natriuretic, diuretic.

Inhibits reabsorption of sodium ions in the ascending knee of the Genle loop, proximal and distal tubules.

Increases excretion of bicarbonates, phosphates, calcium, magnesium.

Indications

Edema in case of circulatory failure, liver and kidney diseases, difficulty in venous outflow, after burns and phlebothrombosis;
ascites (against the background of a malignant neoplasm, liver and cardiac origin);
peripheral edema;
pulmonary edema, incl. threatening, post-traumatic cerebral edema, arterial hypertension;
toxicosis of pregnancy, labor eclampsia, premenstrual tension syndrome, prerenal uremia, hyperkalemia, forced diuresis (poisoning with chemical compounds, including barbiturates).

Pharmacological effect

Furosemide is a natriuretic, diuretic.

Inhibits the reabsorption of sodium ions in the ascending limb of the loop of Henle, proximal and distal tubules.

Increases the excretion of bicarbonates, phosphates, calcium, magnesium.

Special instructions

The drug is prescribed with caution in severe cardiovascular failure, during long-term therapy with cardiac glycosides, as well as in elderly patients with severe atherosclerosis. Before starting treatment, serious disturbances in water and electrolyte balance should be compensated.

Active ingredient

Furosemide

Composition

1 tablet contains:

Active substance:

furosemide 40 mg;

Excipients:

lactose;

potato starch;

MCC;

povidone;

gelatin;

magnesium stearate;

colloidal silicon dioxide;

talc.

Contraindications

Hypersensitivity, anuria, uremia, hepatic coma, mechanical obstruction of the urinary tract, dyselectrolythemia.

Side Effects

From the cardiovascular system: decreased blood pressure, orthostatic hypotension, collapse, tachycardia, arrhythmias, decreased blood volume.

From the central nervous system and peripheral nervous system: dizziness, headache, myasthenia gravis, calf muscle cramps (tetany), paresthesia, apathy, adynamia, weakness, lethargy, drowsiness, confusion.

From the senses: visual and hearing impairment.

From the digestive system: loss of appetite, dry mouth, thirst, nausea, vomiting, constipation or diarrhea, cholestatic jaundice, pancreatitis (exacerbation).

From the genitourinary system: oliguria, acute urinary retention (in patients with prostatic hypertrophy), interstitial nephritis, hematuria, decreased potency.

From the hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia.

From the side of water and electrolyte metabolism: hypovolemia, dehydration (risk of thrombosis and thromboembolism), hypokalemia, hyponatremia, hypochloremia, hypocalcemia, hypomagnesemia, metabolic alkalosis.

Metabolic: hypovolemia, hypokalemia, hyponatremia, hypochloremia, hypokalemic metabolic alkalosis (as a consequence of these disorders – arterial hypotension, dizziness, dry mouth, thirst, arrhythmia, muscle weakness, cramps), hyperuricemia (with possible exacerbation of gout), hyperglycemia.

Allergic reactions: purpura, urticaria, exfoliative dermatitis, exudative erythema multiforme, vasculitis, necrotizing angiitis, itching, chills, fever, photosensitivity, anaphylactic shock.

Other: with intravenous administration (additionally) – thrombophlebitis, renal calcification in premature infants.

Interaction

When furosemide is used simultaneously with cardiac glycosides, the risk of developing glycoside intoxication increases, and when used in combination with corticosteroids, the risk of developing hypokalemia increases.

Overdose

Symptoms: decreased blood pressure, collapse, shock, hypovolemia, dehydration, hemoconcentration, arrhythmias, acute renal failure with anuria, thrombosis, thromboembolism, drowsiness, confusion, flaccid paralysis, apathy.

Treatment: correction of water-salt balance and acid-base status (ABS), replenishment of circulating blood volume, symptomatic treatment.

There is no specific antidote.

Storage conditions

The drug should be stored in a dry place, protected from light, at a temperature not exceeding 25°C.

Shelf life

3 years

Manufacturer

Ozone/Ozone Pharm, Russia