Furadonin Avexima, tablets 50 mg 20 pcs

Pharmgroup:

An antimicrobial agent – nitrofuran.

Pharmic action:

Synthetic broad spectrum antimicrobial agent. Acts bactericidal.

The mechanism of action is associated with the reduction of furadonin into the active intermediate, which damages ribosomal proteins, disrupts the synthesis of protein, DNA, RNA. In high doses it disrupts permeability of the cell membrane of bacteria.

It is active against Gram-positive aerobic bacteria: Staphylococcus spp, Streptococcus spp; against Gram-negative aerobic bacteria: Escherichia coli, Enterobacter spp, Klebsiella spp, Shigella spp.

Weakly active against Enterococcus spp., fungi of the genus Candida.

It is not active against Pseudomonas aeruginosa, Acinetobacter spp.

Most strains of Proteus and Serratia are resistant to furadonin.

Indications

– uncomplicated urinary tract infections (acute cystitis, asymptomatic bacteriuria, urethritis, pyelitis, pyelonephritis);
– prevention of infections during urological operations and examinations (cystoscopy, catheterization).

Active ingredient

Composition

1 tablet:

– nitrofurantoin 50 mg

excipients:

potato starch,

aerosil,

calcium stearate.

How to take, the dosage

Apply orally, with meals, drinking plenty of water.

Adult patients:
Acute uncomplicated urinary tract infections: 50 mg four times daily for seven days. Severe recurrent infection: 100 mg four times daily for seven days.

Long-term maintenance therapy: 50-100 mg once daily.

Preventive therapy: 50 mg four times a day for urological surgeries and examinations and three days thereafter.

Children over 6 years of age:
Acute uncomplicated urinary tract infections: 3 mg/kg/day in four doses for seven days. Maintenance therapy: 1 mg/kg once daily.

In children with a body weight of less than 25 kg it is recommended to use the drug in the form of suspension.

Interaction

Absorption of furadonin is increased when taken with food or with drugs that cause delayed gastric emptying.

Magnesium trisilicate reduces absorption of furadonin.

Probenecid and sulfinpyrazone decrease renal excretion of furadonin.

Corboanhydrase inhibitors and agents that cause alkaline reactions in urine reduce the antibacterial activity of furadonin.
Furadonin and antimicrobials from the fluoroquinolone group are antibacterial antagonists.

Furadonin may inhibit intestinal flora, resulting in decreased estrogen absorption and effectiveness of estrogen-containing contraceptives. Patients are advised to use non-hormonal methods of contraception.

Furadonin may inactivate the oral typhoid vaccine.

Nitrofurantoin weakens the antibacterial effect of norfloxacin in the urinary tract; concomitant use is not recommended.

Special Instructions

The drug should be stopped at the first signs of peripheral neuropathy (paresthesias), since this complication may be life-threatening.

The treatment with furaudonin should be stopped if unexplained symptoms of lung, liver, hematological and neurological disorders occur.

In case of signs of lung damage, furadonin should be stopped immediately. Careful monitoring of pulmonary function is necessary in patients receiving long-term treatment with furadonin, especially in the elderly.
Careful monitoring of patients receiving long-term therapy with furadonin is necessary to detect signs of hepatitis.

The urine may turn yellow or brown after furadonin administration. False-positive reactions may occur in patients receiving furadonin when determining glucose in the urine.

The administration of furadonin should be discontinued if there are signs of hemolysis in patients with suspected glucose-6-phosphate dehydrogenase deficiency.

Gastrointestinal reactions can be minimized if the drug is taken with food, milk, or by reducing the dose.

Pregnancy and lactation. The use during pregnancy of furadonin is contraindicated. If it is necessary to use it during lactation the baby should be weaned for the entire period of treatment.

Pediatric use. It is not recommended for use in children under the age of 6 years.

Cautious use in patients with diabetes, anemia, electrolyte disturbances, and deficiency of B vitamins should be observed because the neurotoxic effect of the drug may increase.

Furadonin should not be used to treat diseases of the cortical substance of the kidneys (glomerulonephritis), purulent paranefritis, prostatitis. Especially for the treatment of parenchymatous infection of one non-functioning kidney. In cases of recurrent or severe infection, surgical causes must be excluded.

The effect on the ability to drive motor vehicles and operate moving machinery. Furadonin may cause dizziness and drowsiness. The patient should not drive a vehicle or operate moving machinery while taking the drug.

Contraindications

– hypersensitivity to nitrofurantoin or nitrofurans;
– marked renal dysfunction, renal failure, oliguria (creatine clearance less than 60 ml/min);
– liver cirrhosis and chronic hepatitis;
– chronic heart failure (III-IV class NYHA). – Children under 6 years old;
– cirrhosis of the liver, chronic hepatitis;
– Chronic heart insufficiency (III-IV class according to NYHA);
– Insufficiency of glucose-6-phosphate dehydrogenase;
– Acute porphyria.
– pregnancy and lactation period because of possible hemolytic anemia in fetus or newborn due to immaturity of erythrocyte enzyme systems.

Side effects

– nausea, vomiting, abdominal pain, diarrhea, hepatitis, cholestatic syndrome, pancreatitis, pseudomembranous enterocolitis.
– dizziness, headache, asthenia, nystagmus, somnolence, peripheral neuropathy.
– interstitial changes in the lungs (interstitial pneumonitis, pulmonary fibrosis), bronchospasm, cough, flu-like syndrome, chest pain.
– leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia.
– lupus-like syndrome, arthralgia, myalgia, anaphylactic reactions, fever, eosinophilia, rash, erythema multiforme exudative (Stevens-Johnson syndrome), exfoliative dermatitis.
– urinary tract superinfection, often caused by Pseudomonas aeruginosa.

Overdose

Symptoms: in high doses dizziness, nausea, vomiting are possible.

Treatment: withdrawal of the drug, taking plenty of fluids to increase excretion of the drug with urine, hemodialysis, symptomatic therapy. There is no specific antidote.

Similarities