Fungoderil, 1% 15 ml

Pharmacotherapeutic group: Antifungal agent

Pharmacodynamics

Naphtifine is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is related to inhibition of squalene-2,3-epoxidase, which reduces the formation of ergosterol, a component of the cell wall of the fungus.

Active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal.

Against yeast fungi naphthifin has fungicidal or fungistatic activity depending on the microorganism strain. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that may cause secondary bacterial infections. It has anti-inflammatory effect, which contributes to the rapid disappearance of inflammatory symptoms, especially itching.

Pharmacokinetics

Indications

Fungal infections of the skin and skin folds (tinea corporis, tinea inquinalis)
interdigital mycoses (tinea manum, tinea pedum)
fungal nail infections (onychomycosis)
skin candidiasis
versicolor (pityriasis versicolor)
ringworm (with or without accompanying itching)

Pharmacological effect

Pharmacotherapeutic group: Antifungal agent

Pharmacodynamics

Naftifine is an antifungal agent for external use, belonging to the class of allylamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus.

Active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (for example, Sporothrix schenckii). Naftifine has a fungicidal effect against dermatophytes and aspergillus.

In relation to yeast fungi, naftifine exhibits fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against gram-positive and gram-negative microorganisms that can cause secondary bacterial infections. It has an anti-inflammatory effect, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

Special instructions

The drug is not intended for use in ophthalmology. The drug should not come into contact with the eyes.

To achieve a therapeutic effect, a course of treatment is required. The drug is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in areas of hair growth.

Active ingredient

Naftifin

Active components

Naftifine hydrochloride 10.0 mg;

Composition

Active ingredient: naftifine hydrochloride 10.0 mg;

Excipients: propylene glycol, ethanol 96%, purified water.

Pregnancy

The use of the drug is contraindicated during pregnancy and breastfeeding (the safety and effectiveness of naftifine in this category of patients has not been studied).

Contraindications

Hypersensitivity to naftifine or other components of the drug; period of pregnancy and breastfeeding (safety and effectiveness of use have not been established), application to the wound surface.

With caution

Children’s age (experience of clinical use is limited).

Side Effects

In some cases, local reactions may be observed: dry skin, skin hyperemia (redness), burning.

Side effects are reversible and do not require discontinuation of treatment.

If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.

Storage conditions

At a temperature not exceeding 30 °C.

Keep out of the reach of children.

Shelf life

2 years. Do not use after expiration date.

Manufacturer

Nizhpharm JSC, Russia