Flogardin, 125 mg 10 pcs.
€26.29 €21.91
Low molecular weight synthetic inducer of interferon which stimulates formation of all types of interferons (alpha, beta, gamma and lambda) in the body. The main producers of interferon in response to tiloron administration are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral administration the maximum production of interferon is determined in the sequence intestine – liver – blood in 4-24 hours. Tiloron has immunomodulatory and antiviral effects.
According to the experimental data after a single oral administration of Tiloron in the dose equivalent to the maximum daily dose for humans, the maximum concentration in the lung tissue of interferon lambda is determined after 24 hours, interferon alpha – after 48 hours. Induction of interferon lambda in the lung tissue enhances antiviral protection of the respiratory tract during influenza and other respiratory viral infections. In human leukocytes tiloron induces synthesis of interferon.
Stimulates bone marrow stem cells, depending on the dose it enhances antibody formation, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers. Effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is associated with inhibition of translation of virus-specific proteins in infected cells, resulting in suppression of virus reproduction.
Pharmacokinetics
After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability is 60%. About 80% of tiloron is bound with plasma proteins. Tiloron is eliminated practically unchanged through intestine (70%) and kidney (9%). The elimination half-life (T1/2) is 48 hours. Tiloron is not biotransformed and does not accumulate in the body.
Indications
As part of the complex therapy in adults:
– treatment of influenza and other acute respiratory infections;
– treatment of herpetic infection.
Prevention of influenza and other acute respiratory infections in adults.
Active ingredient
Composition
Per tablet
The active ingredient:
Tilorone dihydrochloride 125.0000 mg
Excipients:
Microcrystalline cellulose 101 – 120.0000 mg
Potato starch. 46.0000 mg
povidone K 30 – 3.0000 mg
calcium stearate – 3.0000 mg
croscarmellose (croscarmellose sodium) – 3.0000 mg
Shell composition:
VIVACOAT® PC-3P-386 [hypromellose – 6.8100 mg, titanium dioxide – 3.5630 mg, macrogol 4000 – 0.9130 mg, sunset yellow dye (E 110) – 0.3530 mg, quinoline yellow dye (E 104) – 0.2470 mg, polysorbate 80 (tween 80)] – 0.1140 mg.
How to take, the dosage
Internal, after meals.
For adults:
For the treatment of influenza and other acute respiratory infections – 125 mg per day for the first 2 days of treatment, then 125 mg every 48 hours. For a course of 750 mg (6 tablets).
For the prevention of flu and other acute respiratory infections – 125 mg once a week for 6 weeks. For a course of 750 mg (6 tablets).
For the treatment of herpetic infection – the first two days in 125 mg, then in 48 hours in 125 mg. The course dose is 1.25-2.5 g (10-20 tablets).
When treating influenza and other acute respiratory infections, if symptoms persist for more than 4 days, a physician should be consulted.
The drug should only be used according to the indication, route of administration, and dosage listed in the directions.
Interaction
Compatible with antibiotics and drugs for the treatment of viral and bacterial diseases. No clinically significant interaction of tiloron with antibiotics and agents of traditional treatment of viral and bacterial diseases was found.
If you are using the above mentioned or other medicines (including over-the-counter medications), please talk to your doctor before taking Flogardin®.
Special Instructions
The drug contains the dye sunset yellow (E 110), which may cause allergic reactions.
Impact on the ability to drive vehicles, machinery
The drug Flogardin® has no adverse effect on the ability to drive vehicles and engage in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.
Contraindications
Hypersensitivity to tiloron or other ingredients of the drug; pregnancy and breastfeeding; children under 18 years of age.
Side effects
Allergic reactions, dyspeptic phenomena, short-term chills are possible.
If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.
Similarities
Weight | 0.011 kg |
---|---|
Shelf life | 3 years. Do not use after the expiration date. |
Conditions of storage | In the package at a temperature not exceeding 25 ° C. Store out of reach of children. |
Manufacturer | Update PFC AO, Russia |
Medication form | pills |
Brand | Update PFC AO |
Other forms…
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