Flixonase, spray 50 mcg/dose 60 doses

GCS for intranasal use. It has a pronounced anti-inflammatory effect. When administered intranasally there is no systemic action, practically does not inhibit hypothalamic-pituitary-adrenal system.

No significant changes in the daily AUC of serum cortisol were found after administration of fluticasone propionate at a dose of 200 mcg/day compared to placebo (ratio: 1.01, 90% CI – confidence interval from 0.9 to 1.14).

The anti-inflammatory effect of fluticasone propionate is realized as a result of its interaction with glucocorticoid receptors. It suppresses proliferation of mast cells, eosinophils, lymphocytes, macrophages and neutrophils. Fluticasone propionate reduces the production of inflammatory mediators and a number of biologically active substances (including histamine, prostaglandins, leukotrienes, cytokines) during the early and late phase of the allergic reaction. It has rapid anti-inflammatory effect on nasal mucosa.

Anti-allergic effect occurs 2-4 hours after the first use. It reduces sneezing, nasal itching, rhinorrhea, nasal congestion, discomfort in the sinus area and a feeling of pressure around the nose and eyes. Also relieves eye symptoms associated with allergic rhinitis.

Indications

Active ingredient

Composition

1 dose:

Fluticasone propionate (micronized) 50 mcg

Associates:

dextrose – 5 mg,

avicel RC591 (microcrystalline cellulose, sodium carmellose) – 1.5 mg,

phenylethanol – 0.25 mg,

benzalkonium chloride – 0.02 mg,

polysorbate 80 – 0.005 mg,

hydrochloric acid – up to pH 6.3-6.5,

purified water – up to 100 mg.

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use

Similarities