Flexen, 50 mg capsules 30 pcs

Flexen is an NSAID, a derivative of propionic acid.

It has analgesic, anti-inflammatory and antipyretic effects. Mechanism of action is related to inhibition of COX activity – main enzyme of arachidonic acid metabolism which is precursor of prostaglandins, that play main role in pathogenesis of inflammation, pain and fever.

The pronounced analgesic effect of ketoprofen is caused by two mechanisms: peripheral (indirectly, through inhibition of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in central and peripheral nervous system and also due to the effect on biological activity of other neurotropic substances which play key role in release of pain mediators in the spinal cord).

Ketoprofen also has anti-bradykinin activity, stabilizes lysosomal membranes, causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses platelet aggregation.

Indications

Active ingredient

Composition

Active ingredient:

Ketoprofen 50 mg;

Associates:

vegetable oil hydrogenated,

soybean oil hydrogenated,

beeswax.

Capsule shell composition:

gelatin, glycerol, sorbitol, titanium dioxide, sodium ethylparahydroxybenzoate, sodium propylparahydroxybenzoate.

How to take, the dosage

Orally, after a meal, without chewing and with plenty of water, 50-100 mg 2-3 times a day.

Interaction

Because ketoprofen binds significantly to proteins, doses of anticoagulants, diphenylhydantoin or sulfur-containing drugs should be reduced.

Contraindications

Hypersensitivity (including to other NSAIDs), gastrointestinal diseases in the acute phase, marked renal and hepatic dysfunction, leukopenia, thrombocytopenia, blood clotting disorders, hemorrhoids and proctitis (suppositories), pregnancy, lactation, children under 15 years.

Side effects

Gastrointestinal system: gastric pain, nausea, vomiting, diarrhea, flatulence; rarely – bleeding in the gastrointestinal tract; with rectal administration – tenesmus, liquid stools.

CNS disorders: rarely – asthenia, headache, dizziness.

Local reactions: with rectal use – burning.

Others: rare – transient dysuria, skin rash; with external use – skin allergic reactions (itching, urticaria).

Overdose

Treatment: no specific antidote; symptomatic therapy if necessary.

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