Finalagon, cream 35 g

Pharmacodynamics

Nonivamide is a synthetic analog of capsaicin and has analgesic properties, which are manifested as a result of gradual penetration of the active substance into the peripheral nociceptive C-fibers and A-delta nerve fibers when the drug is repeatedly applied to the skin.

Nonivamide has a vasodilator effect, which is accompanied by an intense, prolonged sensation of heat, due to stimulation of afferent nerve endings in the skin. Nicoboxyl is a derivative of nicotinic acid, which has vasodilating properties with the participation of prostaglandins I2 and E2. The hyperemic effect of nicoboxyl (butoxyethyl ester of nicotinic acid) develops faster and has a greater intensity than the hyperemic effect of nonivamide.

Combined action

Nonivamide and nicoboxyl have complementary vasodilatory properties, cause skin hyperemia, increase the rate of enzymatic reactions, and activate metabolism.

The appearance of hyperemia and increase in skin temperature within a few minutes after application are indicative of rapid penetration of the active ingredients of the product into the skin.

The action of Finalegon is localized, develops in a few minutes and reaches its maximum in 20-30 minutes.

Pharmacokinetics

There are no data on the pharmacokinetics of Finalgon®.

Indications

Composition

Associates:

decyl oleate – 50 mg,

emulsifier F – 10 mg,

cetostearyl ether macrogoal – 30 mg,

stearic acid – 2 mg,

cetostearyl alcohol – 20 mg,

liquid paraffin – 30 mg,

sorbic acid – 2 mg,

Parfumed vegetable oil – 2 mg,

Purified water – 823.5 mg.

How to take, the dosage

The treatment should be started by applying a small amount of the ointment to a small area of the skin to assess the individual reaction. Individual reactions to the product can vary widely: some people only need to apply a small amount of ointment to produce the desired warming effect.

With the applicator supplied, a column of ointment no more than 0.5 cm in size is applied to the corresponding palm-sized area of skin, gently rubbing it in. To enhance the therapeutic effect the area of skin where the drug is applied can be covered with a woolen cloth.

The response to the ointment may decrease with repeated use, requiring a higher dose to be adjusted individually.

The cream is used 2-3 times a day if necessary.

To warm up muscles before physical exercise or sports competitions, it is recommended to rub in about 30 minutes beforehand.

The patient should be warned that if the desired effect is not seen within 10 days, a doctor should be consulted.

Wash hands thoroughly with soap and water after application.

Interaction

Special Instructions

The product causes skin hyperemia resulting in redness, heat, itching and burning sensations at the application site. These symptoms may be more pronounced if excessive amounts of the product are applied or if the skin is rubbed vigorously. Use of excessive amounts or intense rubbing of the skin surface may lead to vesicles or pustules where the ointment was applied.

Wash your hands with soap and water immediately after using Finalgon®.

Please be careful to avoid accidental contact with other areas of the skin or contact with another person.

Avoid accidental contact with the face, eyes, nose, or mouth. It can cause temporary swelling of the face, facial pain, conjunctival inflammation, eye hyperemia, burning eyes, visual disturbances, discomfort in the mouth, and stomatitis.

You should not take a hot bath or shower before or after applying the product to the skin.

Sweating or applying heat to the area where the product is applied may cause redness of the skin and an intense sensation of heat even several hours after applying Finalgon.

The product contains sorbic acid, which may cause local skin irritation (such as contact dermatitis).

Impact on ability to drive vehicles and other mechanisms requiring increased attention

There have been no special clinical studies of the effect of the drug on the ability to drive vehicles and mechanisms. However, caution should be exercised while using the drug while driving and operating machinery.

Contraindications

Side effects

During long-term experience with the drug, the following side effects have been identified:

Immune system side effects: anaphylactic reactions, hypersensitivity.

Nervous system disorders: paresthesia, burning sensation of the skin.

Respiratory system disorders: cough, shortness of breath.

Skin and subcutaneous tissue disorders: vesicles or pustules at the application site, local skin reaction (e.g., contact dermatitis), itching, rash, facial edema, urticaria, feeling of heat at the application site.

Overdose

Symptoms: The effects of skin flushing and the severity of dose-dependent side effects may be exacerbated after the use of excessive amounts of Finalgon® ointment. Use of excessive amounts of the drug may cause vesicles or pustules to appear where the ointment is applied.

The drug overdose may cause systemic reactions (redness of the upper body, increased body temperature, blood rush, painful hyperemia, decreased blood pressure) because nicotinic acid esters have good transdermal absorption.

Treatment: if excessive amounts of the drug are used, the effect may be reduced by removing the ointment from the skin surface with vegetable oil or fat-based cosmetic cream, from the mucous membrane of the eye (in case of accidental contact) with medical vaseline. If necessary, symptomatic treatment should be carried out.