Ferrum Lek, 50 mg/ml 2 ml 5 pcs

Ferrum Lek is an anti-anemic drug.

Pharmacodynamics

The drug contains trivalent iron in the form of iron trivalent hydroxide complex with dextran. The iron contained in the preparation quickly makes up for the lack of this element in the body (especially in iron-deficiency anemia), restores the content of hemoglobin. Gradual reduction of both clinical symptoms (weakness, fatigue, dizziness, tachycardia, soreness and dryness of the skin) and laboratory indices of iron deficiency is observed during treatment with the preparation.

Pharmacokinetics

After intramuscular administration of the drug, iron rapidly enters the bloodstream: 15% of the dose after 15 minutes, 44% after 30 minutes. The biological T< sub>1/2 is 3-4 days. Iron in complex with transferrin is transported to body cells, where it is used for the synthesis of hemoglobin, myoglobin and some enzymes. The complex of iron (III) hydroxide with dextran is large enough and therefore is not excreted through the kidneys.

Indications

Treatment of all forms of iron deficiency conditions in which a rapid replenishment of iron is necessary, including the following:

Composition

1 ampoule of solution for intramuscular injection contains:

Active substance:

iron (III) as iron (III) hydroxide complex with dextran 100 mg;

Auxiliary substances:

water for injection.

How to take, the dosage

Intramuscularly (only).

Before administering the first therapeutic dose of the drug, each patient should be given a test dose of 1/4-1/2 ampoule of Ferrum Lek (25-50 mg of iron) for an adult and half the daily dose for a child. If there are no adverse reactions, the remaining part of the daily dose can be administered within 15 minutes.

The doses of Ferrum Lek must be selected individually, according to the total iron deficiency, which is calculated according to the following formula:

Total iron deficiency = body weight (kg) × (estimated hemoglobin level (g/L) – real hemoglobin level (g/L) × 0.24) + deposited iron (mg)

Body weight to 35 kg: Estimated hemoglobin level = 130 g/L and deposited iron = 15 mg/kg

Body weight over 35 kg: Estimated hemoglobin level = 150 g/L and deposited iron = 500 mg

Factor 0.24 = 0.0034 × 0.07 × 1000

(Iron content = 0.34%; total blood volume = 7% of body weight; factor 1000 = conversion from g to mg).

Example

Patient body weight: 70 kg

Real hemoglobin concentration: 80 g/L

Total iron deficiency = (150 – 80) × 0.24 + 500 = 1,700 mg of iron

Total number of vials of Ferrum Lek to be administered = Total iron deficiency (mg) / 100 mg

Calculation of the total number of vials of Ferrum Lek to be administered, based on the real concentration of haemoglobin and body weight

The calculation of the total number of vials of Ferrum Lek to be administered./p> Body weight, kg Total number of Ampules of Ferrum Lek to be injected Hb 60 g/l Hb 75 g/l Hb 90 g/l Hb 105 g/l 5 1.5 1.5 1.5 1 10 3 3 2.5 2 15 5 4.5 3.5 3 20 6.5 5.5 5 4 25 8 7 6 5.5 30 9.5 8.5 7.5 6.5 35 12.5 11.5 10

Interaction

Do not use concomitantly with oral iron-containing drugs.

The concomitant use of ACE inhibitors may increase the systemic effects of parenteral iron drugs.

Special Instructions

Use only in a hospital environment.

When prescribing Ferrum Lek it is necessary to perform laboratory tests: general clinical blood test and determination of serum ferritin; it is necessary to exclude iron absorption disorders.

Ferrum Lec is only for intramuscular administration.

Injection deep into the gluteal muscle (5-6 cm long needle) is mandatory, as well as tissue displacement when inserting the needle and tissue compression after removal of the needle; injected alternately in the right and left gluteal muscles.

The opened ampoule must be used immediately.

The contents of Ferrum Lekne ampoules should be mixed with other medications.

The treatment with oral forms of iron-containing drugs should not be started earlier than 5 days after the last injection of Ferrum Lecne.

In case of improper storage of the drug, precipitation may occur, the use of these ampoules is unacceptable.

Contraindications

With caution: childhood (under 4 months).

Side effects

Inappropriate injection technique may cause staining of the skin, pain, and inflammation at the injection site.

Overdose

Pregnancy use

The drug is contraindicated in the first trimester of pregnancy. In II and III trimesters and during breastfeeding the drug may be used only if the expected benefits to the mother exceed the potential harm to the fetus or infant.