Ferrovir, 15 mg/ml 5 ml 5 pcs

Pharmacodynamics

Ferrovir activates antiviral, antifungal and antimicrobial immunity. It has antiviral action against RNA- and DNA-containing viruses.

The course of treatment (14 days) during the treatment of AIDS/HIV-infection increases the level of CD4+ lymphocytes in blood. This increase continues during 1-1,5 months after the end of treatment. At the same time the viral load in the body decreases, which is reflected in a decrease in the concentration of HIV RNA compared to the initial level.

In case of recurrent herpesvirus infection the duration of relapse is reduced and prolonged remission occurs after 10 days of treatment.

In complex treatment of patients with chronic hepatitis C it improves tolerance of treatment (decrease of dizziness, nausea etc.), reduces replicative activity of HCV of all genotypes and makes process pass to latent phase with restoration of liver cells and inhibition of viral replication. It is active in the presence of viruses of the underlying and opportunistic diseases. There is data on positive therapy with Ferrovir of diseases caused by human papilloma virus and Epstein-Barr virus.

Pharmacokinetics

In intramuscular administration, it is rapidly absorbed and distributed in organs and tissues with participation of the endolymphatic transport route; has a high tropism to the organs of the hematopoietic system; takes an active part in cellular metabolism by incorporating into cellular structures. During daily course of administration it has a property to cumulate in organs and tissues. Time to reach Cmax is 0.5 hours (then the drug concentration in blood starts decreasing due to its distribution in organs and tissues). T1/2 is 36 hours.

When administered repeatedly (every 24 hours during 4 days) the drug accumulates in the spleen, lymph nodes and bone marrow (after the fifth injection the drug concentration in all organs and tissues does not increase, it decreases gradually). The drug is excreted from the body as metabolites, mainly in the urine and partially in the feces. Average retention time of the drug in organs and tissues is 72 hours.

Indications

Active ingredient

Composition

1 ml of solution for intramuscular injection contains:

the active ingredients:

Sodium deoxyribonucleate 15 mg and iron oxide chloride 0.048 mg;

complementary substance:

water for injection.

How to take, the dosage

Ferrovir is administered intramuscularly.

In case of herpetic infection – 5 ml (15 mg/ml) of the solution 2 times a day, for 10 days.

In chronic recurrent genital herpes, cytomegalovirus infection – 5 ml (15 mg/ml) 2 times a day, for 10-15 days.

In the treatment of HIV infection or AIDS, adults – 5 ml (15 mg/ml) of solution for intramuscular injection (75 mg in terms of dry substance) 2 times a day (150 mg), for 14 days. If necessary, in 1-1.5 months a second course of therapy is prescribed.

In the treatment of hepatitis C, Ferrovir is administered intramuscularly 5 ml (15 mg/ml) 2 times a day for 14 days. Over the next 14 days, the drug is administered in the same daily dose every other day.

In case of tick-borne encephalitis – 5 ml (15 mg/ml) 2 times a day for 5 to 10 days.

In papillomavirus infection – 5 ml (15 mg/ml) once a day, 72 hours apart, for 10 days.

In recurrent acute condyloma, either as monotherapy or in combination with surgical treatment, 5 ml (15 mg/ml) of intramuscular solution is given twice daily, for 10 days.

In cases of cervical dysplasia associated with human papilloma virus, the drug is prescribed 5 ml (15 mg/ml) of solution once daily, for 10 days.

If an intramuscular solution of 2 ml is used, recalculate until a course dose of 750 to 2100 mg is reached.

Interaction

Moderately potentiates the effect of anticoagulants.

In complex therapy it reduces toxicity and negative effects of the drugs used (antibacterial, antiviral, antifungal and cytostatics) due to cytoprotective properties and optimization of metabolic processes in hepatocytes.

Special Instructions

To reduce pain, Ferrovir is administered intramuscularly slowly, over 1-2 minutes.

The solution for injection should be fully used immediately after opening the vial; open vials must not be stored.

Intravenous administration of the drug is not allowed!

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Contraindications

Side effects

Transient body temperature increase (up to 38°C), hyperemia and soreness at the injection site may occur.