Fencarol, tablets 25 mg 20 pcs

Phencarol – antiexudative, antipruritic, anti-allergic, anti-edematous.

Pharmacodynamics

The active ingredient of the drug is a blocker of H1-histamine receptors, it prevents the development and facilitates the allergic reactions. It has anti-allergic, antiexudative and antipruritic effects, preventing the development of allergic inflammation in the tissue.

Limits the effect of histamine, reduces its effect on vascular permeability (by reducing permeability it has an anti-edema effect), reduces its bronchospastic action and spasmogenic effect on the smooth muscles of the intestine, weakens the hypotensive effect of histamine.

Hyphenadine reduces the content of histamine in the tissues (due to the ability to activate diamine oxidase – an enzyme that inactivates histamine). With a course of treatment the antihistamine effect of quiphenadine is not reduced. It has moderate antiserotonin action, shows weak m-cholin-blocking activity. It does not have depressing effect on the CNS.

Pharmacokinetics

45% of quiphenadine is quickly absorbed from gastrointestinal tract and is already found in body tissues after 30 minutes. Cmax of active substance in blood plasma is reached after 1 hour. It has low lipophilicity, poor penetration through the BBB.

The highest content of the active substance was noted in liver, a little less in lungs and kidneys, the lowest – in brain (less than 0.05%, which explains the absence of suppressive effect on CNS). Hyphenadine is metabolized in the liver. Metabolites are excreted by the kidneys and intestines. The unabsorbed part of the drug is excreted from the intestine.

Indications

Active ingredient

Composition

Active ingredient:

quiphenadine hydrochloride 25 mg.

Auxiliary substances:

sugar,

potato starch,

calcium stearate.

How to take, the dosage

The drug should be taken orally, after meals. The course of treatment for adults is 10-20 days, repeated if necessary. The course of treatment for children is 10-15 days.

The recommended dosage: adults – 25-50 mg 3-4 times a day (maximum daily dose – 200 mg); children from 2 to 3 years – 5 mg 2-3 times a day; children 3-7 years – 10 mg 2 times a day; children 7-12 years – 10-15 mg 2-3 times a day.

Interaction

Does not increase the depressant effect of alcohol and sleeping pills on the central nervous system.

With weak M-cholin-blocking properties, may decrease gastrointestinal motility and increase absorption of slowly absorbed drugs (e.g., indirect-acting anticoagulants – coumarins).

Special Instructions

The absence of a pronounced cholin-blocking effect allows the use in patients for whom antihistamines with anticholinergic activity are contraindicated.

Impact on the ability to drive and operate machinery: persons whose profession requires rapid mental and motor reactions should first determine (by short-term prescribing) whether the drug has a sedative effect.

Contraindications

With caution for gastrointestinal, hepatic and renal diseases.

Side effects

Digestive system disorders: dry mouth, nausea, vomiting.

CNS disorders: drowsiness, headache.

Others: allergic reactions.

Overdose

Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other dyspeptic phenomena.

Treatment: symptomatic.

It is necessary to flush the stomach, take activated charcoal, see a doctor immediately.

Pregnancy use