Exportal, 10 g 10 pcs
€13.78 €11.49
Laxative
ATX code: A06AD12
Pharmacological properties
In large intestine lactitol is split by intestinal flora into low molecular weight organic acids which cause increase of osmotic pressure in large intestine, increase of volume of stool mass, its softening, facilitation of defecation and normalization of intestinal function. The laxative effect usually occurs within 24 hours after administration of the drug (the delay is due to the passage of the drug through the gastrointestinal tract). At the beginning of treatment it is possible to delay the laxative effect of the drug, the effect may come on the second or third day of its use.
In patients with hepatic encephalopathy or hepatic coma (or precoma) the effect is achieved due to migration of ammonia from blood into the large intestine (due to decrease of pH, increase of osmotic pressure in the intestinal lumen), removal of delayed ammonium ions and other nitrogen-containing toxic substances from the large intestine. Lactitol suppresses proteolytic bacteria and increases the number of acidophilic bacteria, thus restoring the microbiome.
Pharmacokinetics.
Lactitol exerts its effect only in the large intestine, where it enters completely after ingestion. It is absorbed in minimal amounts in unchanged form (not more than 0.5 – 2% of the dose taken).
Indications
Constipation, the need to regulate stool for medical purposes (cleansing the intestines in preparation for endoscopic and x-ray examinations, surgical interventions on the rectum, anal sphincter and the area adjacent to it), intestinal dysbiosis.
Hepatic encephalopathy, hepatic precoma and coma, hyperammonemia.
Pharmacological effect
Laxative
ATX code: A06AD12
Pharmacological properties
In the large intestine, lactitol is broken down by intestinal flora into low-molecular organic acids, which leads to an increase in osmotic pressure in the large intestine, an increase in the volume of feces, their softening, easier bowel movements and normalization of intestinal function. The laxative effect usually occurs within 24 hours after using the drug (the delay is due to the passage of the drug through the gastrointestinal tract). At the beginning of the course of treatment, the laxative effect of the drug may be delayed; the effect may occur on the second or third day of its use.
In patients with hepatic encephalopathy or hepatic coma (or precoma), the effect is achieved due to the migration of ammonia from the blood into the large intestine (due to a decrease in pH, an increase in osmotic pressure in the intestinal lumen), removal of retained ammonium ions and other nitrogen-containing toxic substances from the colon. Lactitol inhibits proteolytic bacteria and increases the number of acidophilus bacteria, thus restoring the microbiome.
Pharmacokinetics.
Lactitol exerts its effect only in the large intestine, where it is completely absorbed after ingestion. It is absorbed in minimal quantities unchanged (no more than 0.5 – 2% of the dose taken).
Special instructions
Lactitol has a low calorie content (2 kcal/g), does not affect blood glucose levels and can be used in patients with diabetes.
Throughout the entire course of use of the drug, increased fluid intake is desirable.
The use of Exportal® does not affect psychomotor functions associated with driving a car or operating machines and mechanisms.
Active ingredient
Lactitol
Composition
Lactitol monohydrate – 5 g or 10 g per sachet, 200 g or 500 g in plastic containers. No excipients.
Pregnancy
Due to the minimal absorption of lactitol, any adverse effects on the woman and fetus when used during pregnancy are not expected. The drug can be taken during pregnancy if the potential benefit to the mother outweighs the potential risk to the fetus.
Due to minimal absorption, lactitol is not expected to pass into breast milk. The drug can be taken during breastfeeding if the potential benefit to the mother outweighs the potential risk to the baby.
Contraindications
Hypersensitivity to lactitol.
Lactase deficiency, fructose and galactose intolerance, galactosemia, glucose-galactose malabsorption syndrome.
Syndrome of complete or partial intestinal obstruction, suspicion of organic damage to the gastrointestinal tract, abdominal pain and rectal bleeding of unknown origin, inflammatory bowel diseases (rectocolitis, regional enteritis), previous disturbance of water-salt balance.
Children’s age up to 1 year.
With caution
Exportal® should be used with caution in patients prone to water-salt imbalance.
Side Effects
At the beginning of treatment, you may experience abdominal discomfort, flatulence and, in rare cases, abdominal pain and bloating. These phenomena, as a rule, disappear with continued use of the drug, as you adapt to it.
If higher doses are used for a long time in the treatment of hepatic encephalopathy in a patient due to diarrhea, due to individual differences, some patients may experience diarrhea even when taking the recommended dose of the drug. In this case, it is necessary to reduce the dose of the drug.
The frequency of side effects is classified in accordance with the recommendations of the World Health Organization: very often – at least 10%; often – at least 1%, but less than 10%; infrequently – not less than 0.1%, but less than 1%; rarely – not less than 0.01%, but less than 0.1%; very rarely – less than 0.01%; unknown frequency – cannot be estimated based on available data.
Gastrointestinal disorders
Rarely: flatulence, abdominal pain, bloating, vomiting, diarrhea.
Very rare: nausea, anal itching.
Interaction
When taking Exportal® simultaneously with enteric pH-dependent release drugs, it should be taken into account that lactitol lowers the intestinal pH.
It is not recommended to use Exportal® within two hours after taking other medications.
Overdose
Symptoms: diarrhea, abdominal pain, and in rare cases, vomiting. These phenomena are usually eliminated by reducing the dose of the drug.
Treatment: dose reduction or drug withdrawal. Correction of possible violations of water-salt balance.
Storage conditions
In a dry place, protected from light and out of reach of children.
Shelf life
5 years. Not
Use after the expiration date indicated on the package.
Manufacturer
PharmVilar NPO LLC, Russia
Shelf life | 5 years. Do not use after the expiration date stated on the package. |
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Conditions of storage | In a dry place, protected from light and out of the reach of children. |
Manufacturer | PharmVilar NGO, Russia |
Medication form | Powder for preparation of solution for oral administration |
Brand | PharmVilar NGO |
Other forms…
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