Exportal, 10 g 10 pcs

Laxative

ATX code: A06AD12

Pharmacological properties

In large intestine lactitol is split by intestinal flora into low molecular weight organic acids which cause increase of osmotic pressure in large intestine, increase of volume of stool mass, its softening, facilitation of defecation and normalization of intestinal function. The laxative effect usually occurs within 24 hours after administration of the drug (the delay is due to the passage of the drug through the gastrointestinal tract). At the beginning of treatment it is possible to delay the laxative effect of the drug, the effect may come on the second or third day of its use.

In patients with hepatic encephalopathy or hepatic coma (or precoma) the effect is achieved due to migration of ammonia from blood into the large intestine (due to decrease of pH, increase of osmotic pressure in the intestinal lumen), removal of delayed ammonium ions and other nitrogen-containing toxic substances from the large intestine. Lactitol suppresses proteolytic bacteria and increases the number of acidophilic bacteria, thus restoring the microbiome.

Pharmacokinetics.

Lactitol exerts its effect only in the large intestine, where it enters completely after ingestion. It is absorbed in minimal amounts in unchanged form (not more than 0.5 – 2% of the dose taken).

Indications

Hepatic encephalopathy, hepatic precoma and coma, hyperammonemia.

Active ingredient

Composition

How to take, the dosage

In constipation and dysbacteriosis. The drug should be taken once, the entire daily dose at once, at one time.

Children 1 to 6 years of age -2.5 to 5 g (1/2 to 1 teaspoon of powder) daily.

Children 6 -12 years -5 – 10 g (1 – 2 teaspoons of powder) per day.

Children 12 -16 years -10 – 20 g (2 – 4 teaspoons of powder) per day.

Adults: 20 g (4 teaspoons of powder) per day.

The drug should induce stools once daily; after a few days of steady laxative effect, the dose may be reduced. In some cases half the recommended daily dose may be enough to have the desired effect:

In children 1-6 years of age 1.25-2.5 g (1/4-1/2 teaspoons of powder) daily.

Children 6-12 years – 2.5 to 5 g (1/2 to 1 teaspoon of powder) per day.

Children 12-16 years – 5 – 10 g (1 – 2 teaspoons of powder) per day.

Adults: 10 g (2 teaspoons of powder) per day.

The minimum course of therapy after which it is necessary to consult a physician is 5 months. It is recommended to use the drug in children under the supervision of a doctor.

In the regulation of stools for medical purposes. Take 20 g of the drug diluted in 1 liter of water three times (at 12, 15 and 18 hours) on the eve of medical procedures.

In hepatic encephalopathy, hepatic precoma and coma, hyperammonemia. The dose of the drug should be chosen individually for each patient, depending on the degree of severity of the disease and the individual response to the drug. Initial daily dose is usually 0.5-0.7 g per 1 kg of body weight. This dose is divided into three single doses. It is taken with meals. A dose that causes two “soft” stools per day should be chosen.

Interaction

When taking Exportal® concomitantly with intestinal pH-dependent release drugs, note that lactitol lowers intestinal pH.

The use of Exportal® within two hours of taking other medications is not recommended.

Special Instructions

Lactitol has a low caloric value (2 kcal/g), does not affect blood glucose levels and can be used in diabetic patients.

Higher fluid intake is advisable during the entire course of the drug.

The use of Exportal® has no effect on the psychomotor functions associated with driving or operating machinery.

Synopsis

Contraindications

Hypersensitivity to lactitol.

Lactase deficiency, fructose and galactose intolerance, galactosemia, glucose-galactose malabsorption syndrome.

The syndrome of complete or partial intestinal obstruction, suspected organic damage of the gastrointestinal tract, abdominal pain and rectal bleeding of unclear genesis, inflammatory bowel disease (rectocolitis, regional enteritis), previous water-salt imbalance.

Children under 1 year of age.

Cautions

Exportal® should be used with caution in patients who are prone to disorders of the water-salt balance.

Side effects

At the beginning of treatment, there may be a feeling of discomfort in the abdomen, flatulence and, in rare cases, abdominal pain and bloating. These phenomena usually disappear with continued use of the drug as we adapt to it.

If higher doses are used over an extended period of time while treating a patient with hepatic encephalopathy, diarrhea may occur even with the recommended dose of the drug due to individual differences in some patients. In this case, it is necessary to reduce the dose of the drug.

The incidence of side effects is classified according to the recommendations of the World Health Organization: very common – at least 10%; common – at least 1%, but less than 10%; infrequent – at least 0.1%, but less than 1%; rare – at least 0.01%, but less than 0.1%; very rare – less than 0.01%; unknown frequency – cannot be estimated based on available data.

Gastrointestinal disorders

Rare: flatulence, abdominal pain, abdominal bloating, vomiting, diarrhea.

Very rare: nausea, anal itching.

Overdose

Symptoms: diarrhea, abdominal pain, vomiting may occur in rare cases. These phenomena are usually resolved by reducing the dose of the drug.

Treatment: dose reduction or discontinuation of the drug. Correction of possible water-salt balance disorders.

Pregnancy use

Due to the minimal absorption of lactitol, no adverse effects on the woman or the fetus are expected with its use during pregnancy. The drug can be taken during pregnancy if the potential benefit to the mother is greater than the potential risk to the fetus.

With minimal absorption, no penetration of lactitol into breast milk is expected. The drug may be taken during breastfeeding if the potential benefit to the mother exceeds the potential risk to the baby.

Similarities