Exorolfinlac, nail polish 5% 2.5ml
€31.00 €25.83
Pharmacodynamics
. The active ingredient of Exorolfinlac, amorolfin, provides its fungistatic and fungicidal efficacy due to the destruction of the cytoplasmic fungal membrane through disruption of sterol biosynthesis, thus reducing ergosterol levels and cumulating atypical stereoisomers – steric flat sterols.
Owing to the wide spectrum of action amorolfin is highly active against not only the most common but also rare fungal pathogens affecting the nail plate: dermatophytes: Microsporum spp, Trichophyton spp., Epidermophyton spp.; yeast fungi: Candida spp., Malassezia spp. (Pityrosporum spp.), Cryptococcus spp.; mold fungi: Scopulariopsis spp., Alternaria spp, Hendersonula spp.; fungi of the family Dematiaceae: Fonsecaea spp., Cladosporium spp., Wangiella spp.; dimorphic fungi: Histoplasma spp., Coccidioides spp., Sporothrix spp.
Pharmacokinetics
After application of the nail polish into the nail plate and further into the nail bed amorolfin penetrates almost completely during the first 24 hours. The effective concentration of the substance is maintained in the affected area for 7 to 10 days, even after the first application. It is only slightly absorbed systemically and the plasma concentration is below the sensitivity limit of the assay (< 0.5 ng/ml).
Indications
According to the instructions, Exorolfinlac is recommended for local treatment of fungal lesions of the nail plates caused by yeast fungi, dermatophytes and molds.
Active ingredient
Amorolfin
Composition
per ml of varnish:
the active ingredient:
amorolfin – 50 mg (in the form of amorolfin hydrochloride – 55.74 mg);
auxiliary ingredients:
Ethyl acetate, 150 mg;
Triacetin, 10.5 mg;
eudragit RL PO (methacrylic acid copolymer) – 125 mg;
butyl acetate – 50 mg;
ethanol – 480 mg.
Directions for use
Exorolfinlac is designed for external application to the affected toe and/or finger nail plates. The procedure is performed 1-2 times a week, observing the following recommendations: Before applying the drug, with the disposable file included in the kit, if possible, remove the affected fragments of the nail, especially from its surface.
Special Instructions
During Exorolfinlac treatment it is necessary: Do not use files used to treat the affected nails to treat healthy nail plates. When working with organic solvents to protect the nails coated with the drug, wear impermeable gloves. Avoid the use of artificial superimposed nails.
Contraindications
- pregnancy and lactation;
- children and adolescents under 18 years of age;
- hypersensitivity to amorolfin and other components of the drug.
.
Side effects
The use of the drug Exorolfinlac causes adverse reactions in rare cases.
Overdose
The drug is used exclusively for external use, in which systemic signs of overdose are not expected to develop.
Pregnancy use
Data on the use of amorolfin in pregnancy and during breastfeeding are limited, and therefore the use of Exorolfinlac during these periods is not recommended.
Similarities
Lotseril, Oflomil nail polish, Onichelp, Amorolfin
Weight | 0.108 kg |
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Shelf life | After opening the bottle should be used within 6 months. |
Conditions of storage | Store in a place protected from light, inaccessible to children, up to 25 ° C. |
Manufacturer | Paul W. Beifers GmbH, Germany |
Medication form | nail polish |
Brand | Paul W. Beifers GmbH |
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