Exorolfinlac, nail polish 5% 2.5ml
€31.00 €25.83
Pharmacodynamics
. The active ingredient of Exorolfinlac, amorolfin, provides its fungistatic and fungicidal efficacy due to the destruction of the cytoplasmic fungal membrane through disruption of sterol biosynthesis, thus reducing ergosterol levels and cumulating atypical stereoisomers – steric flat sterols.
Owing to the wide spectrum of action amorolfin is highly active against not only the most common but also rare fungal pathogens affecting the nail plate: dermatophytes: Microsporum spp, Trichophyton spp., Epidermophyton spp.; yeast fungi: Candida spp., Malassezia spp. (Pityrosporum spp.), Cryptococcus spp.; mold fungi: Scopulariopsis spp., Alternaria spp, Hendersonula spp.; fungi of the family Dematiaceae: Fonsecaea spp., Cladosporium spp., Wangiella spp.; dimorphic fungi: Histoplasma spp., Coccidioides spp., Sporothrix spp.
Pharmacokinetics
After application of the nail polish into the nail plate and further into the nail bed amorolfin penetrates almost completely during the first 24 hours. The effective concentration of the substance is maintained in the affected area for 7 to 10 days, even after the first application. It is only slightly absorbed systemically and the plasma concentration is below the sensitivity limit of the assay (< 0.5 ng/ml).
Indications
Active ingredient
Composition
per ml of varnish:
the active ingredient:
amorolfin – 50 mg (in the form of amorolfin hydrochloride – 55.74 mg);
auxiliary ingredients:
Ethyl acetate, 150 mg;
Triacetin, 10.5 mg;
eudragit RL PO (methacrylic acid copolymer) – 125 mg;
butyl acetate – 50 mg;
ethanol – 480 mg.
Directions for use
Special Instructions
Contraindications
Side effects
Overdose
Pregnancy use
Similarities
Weight | 0.108 kg |
---|---|
Shelf life | After opening the bottle should be used within 6 months. |
Conditions of storage | Store in a place protected from light, inaccessible to children, up to 25 ° C. |
Manufacturer | Paul W. Beifers GmbH, Germany |
Medication form | nail polish |
Brand | Paul W. Beifers GmbH |
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