Exoderil, 1% 20 ml

Pharmacological group:

antifungal agent

ATC code: D01AE22

Pharmacodynamics

Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is related to inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol, which is a part of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton, Epidermophyton and Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii).

With respect to dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections. It has anti-inflammatory activity, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

Naftifin quickly penetrates the skin, creating sustained antifungal concentrations in its various layers, making once-daily use possible

Indications

– fungal infections of the skin and skin folds (tinea corporis, tinea inguinalis), including. interfinger mycoses (tinea manum, tinea pedum);

– fungal infections of the nails (onychomycosis);

– Candidiasis of the skin;

– chancroid;

– dermatomycoses (with or without associated itching).

Exoderil® is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in areas of hair growth.

Active ingredient

Composition

1 ml of the solution contains:

active ingredient:

naphthyphine hydro-chloride – 10 mg;

excipients:

propylene glycol – 50 mg,

ethanol – 400 mg,

purified water – 475 mg.

How to take, the dosage

Externally. Exoderil® is applied once a day to the affected skin surface and its neighboring areas (about 1 cm of healthy skin at the edges of the affected area) after their thorough cleaning and drying.

The therapy duration is 2-4 weeks in dermatomycosis (if necessary – up to 8 weeks), with candidiasis – 4 weeks. In case of nail affection, Exoderil® is applied twice a day on the affected nail.

Before the first use of the drug, remove the affected part of the nail with scissors or a nail file as much as possible. The duration of therapy for onychomycosis is up to 6 months.

To prevent relapse, treatment should be continued for at least 2 weeks after the disappearance of clinical symptoms.

Interaction

No drug interactions of Exoderil® with other drugs were noted.

Special Instructions

Precautions for use:

The drug Exoderil® is not intended for use in ophthalmology. Avoid contact of the drug with the eyes.

Impact on the ability to drive vehicles and other machinery:

Exoderil® has no adverse effect on the ability to drive vehicles and perform other activities requiring concentration and rapid psychomotor reactions.

Contraindications

Hypersensitivity to naphthyphine or propylene glycol; pregnancy and lactation (safety and efficacy of use have not been determined).

Application on the wound surface is contraindicated.

With caution

Children (experience with clinical use is limited).

Side effects

In some cases, local reactions may be observed: dry skin, skin hyperemia and burning.

The side effects are reversible and do not require treatment withdrawal.

Overdose

No cases of overdose have been reported.

Similarities