Exoderil, cream 1% 15 g

Antifungal agent

ATX code: D01AE22

Pharmacodynamics

Naftifine is a topical antifungal agent belonging to the class of allilamines. Its mechanism of action is related to inhibition of squalene-2,3-epoxidase, which results in reduction of formation of ergosterol, a component of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton, Epidermophyton and Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal.

The drug has fungicidal or fungistatic activity against yeast fungi depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms which may cause secondary bacterial infections. It has anti-inflammatory activity, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

When applied externally, it penetrates well into various layers of the skin, creating sustained antifungal concentrations in its various layers. After application on the skin, less than 6% of naphthifin is absorbed systemically. Absorbed amount is partially metabolized and excreted by kidneys and intestine. Half-life period of the drug is 2 – 3 days.

Indications

Skin fungus, Skin itch, Nail fungus, Fungus

– fungal infections of the skin and skin folds (tinea corporis, tinea inguinalis), including. interfinger mycoses (tinea manum, tinea pedum);

– fungal infections of the nails (onycho-mycoses);

– Candidiasis of the skin;

– chancroid;

– dermatomycoses (with or without associated itching).

Active ingredient

Naftifin

Composition

1 g of cream contains:

the active ingredient:

naphthyphine hydrochloride – 10.0 mg.

accompanies:

sodium hydroxide – 1.2 mg,

benzyl alcohol – 10.0 mg,

sorbitan stearate – 19.0 mg,

cetyl palmitate – 20.0 mg,

cetyl alcohol – 40.0 mg,

stearyl alcohol – 40.0 mg,

polysorbate 60 – 61.0 mg,

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isopropyl myristate – 80.0 mg,

purified water – 718.8 mg.