Exchol, 250 mg capsules 10 pcs

Exchol – hepatoprotective agent, has a choleretic effect. It reduces the synthesis of cholesterol in the liver, its absorption in the intestine and its concentration in the bile, increases the solubility of cholesterol in the biliary system, stimulates the formation and excretion of bile.

Limits bile lithogenicity, increases the content of bile acids in it; causes intensification of gastric and pancreatic secretion, increases lipase activity, has hypoglycemic effect. Causes partial or complete dissolution of cholesterol stones in enteral administration, reduces bile saturation with cholesterol, which promotes mobilization of cholesterol from gallstones. It has an immunomodulatory effect, affects immunological reactions in the liver: it reduces the expression of some antigens on the membrane of hepatocytes, affects the number of T-lymphocytes, interleukin -2 formation, reduces the number of eosinophils.

Pharmacokinetics

The absorption from the small intestine is high (about 90%). Passes through the placental barrier. Maximum concentration (Cmax) at oral administration of 50 mg after 30, 60, 90 min is 3.8, 5.5, 3.7 mmol/l, respectively. Time of reaching maximum concentration (TCmax) is 1-3 hours. Binding to plasma proteins is high.

It is metabolized in the liver (clearance during “primary passage” through the liver) into taurine and glycine conjugates. The resulting conjugates are secreted into the bile. Excreted 50-70% through the intestine.

A small amount of unabsorbed ursodeoxycholic acid enters the large intestine, where it undergoes cleavage by bacteria (7-dehydroxylation); the resulting lithocholic acid is partially absorbed from the colon, but is sulfated in the liver and rapidly excreted as sulfolithocholylglycine or sulfolithocholyltaurine conjugate.

Indications

Primary biliary cirrhosis in the absence of signs of decompensation (symptomatic therapy),
dissolution of small and medium-sized cholesterol stones with a functioning gallbladder,
biliary reflux – gastritis.

Pharmacological effect

Exchol is a hepatoprotective agent and has a choleretic effect. Reduces cholesterol synthesis in the liver, its absorption in the intestines and concentration in bile, increases the solubility of cholesterol in the biliary system, stimulates the formation and secretion of bile.

Reduces the lithogenicity of bile, increases the content of bile acids; causes increased gastric and pancreatic secretion, enhances lipase activity, and has a hypoglycemic effect. Causes partial or complete dissolution of cholesterol stones when administered enterally, reduces the saturation of bile with cholesterol, which promotes the mobilization of cholesterol from gallstones. It has an immunomodulatory effect, affects immunological reactions in the liver: it reduces the expression of certain antigens on the hepatocyte membrane, affects the number of T-lymphocytes, the formation of interleukin-2, and reduces the number of eosinophils.

Pharmacokinetics

Absorption from the small intestine is high (about 90%). Penetrates through the placental barrier. The maximum concentration (Cmax) when taken orally 50 mg after 30, 60, 90 minutes is 3.8, 5.5, 3.7 mmol/l, respectively. The time to reach maximum concentration (TCmax) is 1-3 hours. The connection with plasma proteins is high.

Metabolized in the liver (first pass clearance through the liver) into taurine and glycine conjugates. The resulting conjugates are secreted into bile. It is excreted 50-70% through the intestines.

A small amount of unabsorbed ursodeoxycholic acid enters the large intestine, where it is broken down by bacteria (7-dehydroxylation); the resulting lithocholic acid is partially absorbed from the colon, but is sulfated in the liver and quickly excreted in the form of sulfolithocholylglycine or sulfolitocholyltaurine conjugate.

Active ingredient

Ursodeoxycholic acid

Composition

1 capsule contains:

active substance:

ursodeoxycholic acid 250 mg;

excipients:

colloidal silicon dioxide (Aerosil A-200 or A-300),

calcium hydrogen phosphate dihydrate,

magnesium stearate,

povidone (plasdon K-90 or collidon 90 F),

lactose monohydrate (milk sugar);

composition of the hard gelatin capsule:

body – titanium dioxide, gelatin; cap – titanium dioxide, gelatin, indigo carmine.

Contraindications

Hypersensitivity,
X-ray positive (high Ca2+ content) gallstones,
non-functioning gallbladder,
bile-gastrointestinal fistula,
chronic hepatitis,
inflammatory diseases of the small and large intestine,
acute cholangitis,
liver and/or kidney failure,
pancreatitis,
obstruction of the biliary tract,
acute infectious diseases of the gallbladder and bile ducts,
empyema of the gallbladder,
pregnancy,
lactation period,
childhood.

Side Effects

Back pain
diarrhea (may be dose dependent),
abdominal pain,
calcification of gallstones,
increased activity of “liver” transaminases,
alopecia,
constipation,
dizziness,
nausea,
exacerbation of previously existing psoriasis,
vomit,
allergic reactions.

Interaction

Antacids containing Al3+ and ion exchange resins (colestyramine) reduce absorption.

Lipid-lowering drugs (especially clofibrate), estrogens, neomycin, or progestins increase the saturation of bile with cholesterol and may reduce the ability to dissolve cholesterol gallstones.

Overdose

No cases of overdose have been identified. In case of overdose, symptomatic treatment is carried out.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C.

Shelf life

3 years

Manufacturer

Kanonpharma production CJSC, Russia