Exchol, 250 mg capsules 10 pcs

Exchol – hepatoprotective agent, has a choleretic effect. It reduces the synthesis of cholesterol in the liver, its absorption in the intestine and its concentration in the bile, increases the solubility of cholesterol in the biliary system, stimulates the formation and excretion of bile.

Limits bile lithogenicity, increases the content of bile acids in it; causes intensification of gastric and pancreatic secretion, increases lipase activity, has hypoglycemic effect. Causes partial or complete dissolution of cholesterol stones in enteral administration, reduces bile saturation with cholesterol, which promotes mobilization of cholesterol from gallstones. It has an immunomodulatory effect, affects immunological reactions in the liver: it reduces the expression of some antigens on the membrane of hepatocytes, affects the number of T-lymphocytes, interleukin -2 formation, reduces the number of eosinophils.

Pharmacokinetics

The absorption from the small intestine is high (about 90%). Passes through the placental barrier. Maximum concentration (Cmax) at oral administration of 50 mg after 30, 60, 90 min is 3.8, 5.5, 3.7 mmol/l, respectively. Time of reaching maximum concentration (TCmax) is 1-3 hours. Binding to plasma proteins is high.

It is metabolized in the liver (clearance during “primary passage” through the liver) into taurine and glycine conjugates. The resulting conjugates are secreted into the bile. Excreted 50-70% through the intestine.

A small amount of unabsorbed ursodeoxycholic acid enters the large intestine, where it undergoes cleavage by bacteria (7-dehydroxylation); the resulting lithocholic acid is partially absorbed from the colon, but is sulfated in the liver and rapidly excreted as sulfolithocholylglycine or sulfolithocholyltaurine conjugate.

Indications

Active ingredient

Composition

1 capsule contains:

the active ingredient:

ursodeoxycholic acid 250 mg;

auxiliary substances:

colloidal silicon dioxide (aerosil A -200 or A -300),

calcium hydrophosphate dihydrate,

magnesium stearate,

p> povidone (plasdon K-90 or collidon 90 F),

lactose monohydrate (milk sugar);

composition of hard gelatin capsule:

casing – titanium dioxide, gelatin; cap – titanium dioxide, gelatin, indigo carmine.

How to take, the dosage

Exchol is taken orally.

For dissolution of cholesterol gallstones, the average daily dose is 10 mg/kg. The course of treatment is 6-12 months. To prevent recurrent stone formation, it is recommended to continue taking the drug for several months after the stones have been dissolved.

In biliary reflux gastritis the dose is 250 mg once a day. The course of treatment is from 10 -14 days to 6 months, if necessary – up to 2 years.

The symptomatic therapy of primary biliary cirrhosis: daily dose is 10-15 mg/kg. Capsules are taken in the evening, without chewing, with a small amount of water. Patients with body weight less than 34 kg are recommended to take the drug in the form of suspension.

Interaction

Antacids containing Al3+ and ion exchange resins (colestyramine) reduce absorption.

Hypolipidemic drugs (especially clofibrate), estrogens, neomycin or progestins increase bile cholesterol saturation and may decrease the ability to dissolve cholesterol-containing bile concretions.

Contraindications

Side effects

Overdose

No cases of overdose have been identified. In case of overdose symptomatic treatment is administered.

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