Etoxysclerol, 5 mg/ml 2 ml 5 pcs

Etoxysclerol has a venosclerosing, local anesthetic effect. It damages the vascular endothelium, causing denaturation of proteins, stimulates rapid thrombus formation and its organization within 7 days.

Ethoxysclerol reduces the excitability of nerve endings and the conduction of the pain impulse, ensuring painless sclerotherapy.

The volume of distribution is 24.5 L, plasma protein binding is 64%, T_1/2 is 4 hours. Total Cl – 11.7 l/h, renal – 2.43 l/h, biliary – 3.14 l/h. It does not cumulate with repeated injections.

Indications

Symptomatic treatment for functional asthenia.

Active ingredient

Composition

Active substance:

polidocanol 5 mg.

How to take, the dosage

Ethoxysclerol is administered strictly intravenously with the leg horizontal or elevated 30-45°.

The total dose of polydocanol in sclerosing varicose veins and hemorrhoids should not exceed 2 mg/kg body weight per day.

For a patient weighing 70 kg, up to 140 mg of polidocanol can thus be administered (28 ml of 0.5% etoxysclerol solution, 14 ml of 1% etoxysclerol solution, 4.6 ml of 3% etoxysclerol solution).

Interaction

It enhances arrhythmogenic activity of local anesthetics and drugs for general anesthesia.

Special Instructions

Compensated CHF and stable arterial hypertension are not contraindications to sclerosing therapy.

Sclerosing drugs should not be administered by mouth, as this may lead to severe necrosis and forced amputation.

In case of accidental intra-arterial injection – inject 5-10 ml of 1-2% lidocaine or mepivacaine solution, 500 IU heparin into the needle left in the artery; wrap the limb with absorbent cotton and put it down; hospitalize patient in a vascular surgery department.

Injection of sclerosing drugs into the facial veins of the skull only with strict indications.

Contraindications

Ethoxysclerol hypersensitivity, bronchial asthma, diabetes mellitus

Side effects

In sclerosing varicose veins of the extremities: hyperpigmentation of the skin at the site of Etoxysclerol injection.

In sclerosing hemorrhoids: transient pain.

In sclerosing varicose veins of the esophagus and stomach: necrosis, esophageal ulceration and stenosis, exudation into the pleural cavity, dysphagia, fever, anaphylactic shock.

Overdose

Symptoms: with paravasal injection – necrosis.

Treatment: injection of 0.5-2 ml of 1% procaine solution or 5-20 ml of 0.9% NaCl solution in combination with hyaluronidase.

Pregnancy use

It is contraindicated in the first trimester of pregnancy and after 36 weeks;

Breastfeeding after administration of Etoxysclerol is recommended to stop for 2-3 days.