Etoxysclerol, 10 mg/ml 2 ml 5 pcs

Etoxysclerol has a venosclerosing, local anesthetic effect. It damages the vascular endothelium, causing denaturation of proteins, stimulates rapid thrombus formation and its organization within 7 days.

Ethoxysclerol reduces the excitability of nerve endings and the conduction of the pain impulse, ensuring painless sclerotherapy.

Pharmacokinetics

The volume of distribution is 24.5 L, binding to plasma proteins is 64%, T1/2 is 4 hours. Total Cl – 11.7 l/h, renal – 2.43 l/h, biliary – 3.14 l/h. It does not cumulate with repeated injections.

Indications

Sclerotherapy of varicose veins and telangiectasia, hemorrhoids;

obliteration or parietal sclerosis of varicose veins of the esophagus and stomach in case of acute bleeding from varicose veins of the esophagus and the condition after it, complete thrombosis of the portal vein, shunt thrombosis with intrahepatic block, etc.

Pharmacological effect

Ethoxysclerol has a venosclerosing, local anesthetic effect. Damages the vascular endothelium, causing denaturation of proteins, stimulates the rapid formation of a blood clot and its organization within 7 days.

Ethoxysklerol reduces the excitability of nerve endings and the conductivity of pain impulses, ensuring painlessness of sclerotherapy.

Pharmacokinetics

Volume of distribution – 24.5 l, plasma protein binding – 64%, T1/2 – 4 hours. Total Cl – 11.7 l/h, renal – 2.43 l/h, biliary – 3.14 l/h. Does not accumulate with repeated administrations.

Special instructions

Cannot be administered intra-arterially. When used in the ankle and ankle area, small amounts of a 0.5% solution are recommended.

When sclerosing saphenous veins and telangiectasias, the injection site is pressed with a tampon and a compression bandage is immediately applied; After the procedure, the patient must walk for 30 minutes.

The bandage compresses the walls of the veins, which prevents recanalization and promotes the formation of a fibrous scar.

When sclerosing telangiectasia, a bandage is applied for 2–3 days; for severe varicose veins, compression with elastic bandages or medical stockings of classes II-III is recommended for 4–6 weeks.

Active ingredient

Lauromacrogol-400

Composition

1 ml of injection solution contains:

Active ingredient:

polidocanol 10 mg

Pregnancy

Contraindicated in the first trimester of pregnancy and after 36 weeks; It is recommended to stop breastfeeding after administration of Ethoxysklerol for 2-3 days.

Contraindications

Absolute:

hypersensitivity,
shock,
bed rest,
diseases,
caused by blockage of the artery of III-IV degree,
chronic arterial insufficiency,
acute inflammatory diseases in the area of ​​sclerosis.

Relative:

thrombosis of superficial and deep (especially) veins,
swelling,
symptoms of diabetic microangiopathy,
acute and chronic heart diseases (endocarditis, myocarditis),
feverish conditions,
diseases caused by artery blockage II degree (for cosmetic indications),
bronchial asthma.

Side Effects

When sclerosing varicose veins of the extremities: hyperpigmentation of the skin at the injection site.

When sclerosing hemorrhoids: transient pain.

When sclerosing varicose veins of the esophagus and stomach: necrosis, ulceration and stenosis of the esophagus, exudation into the pleural cavity, dysphagia, fever, anaphylactic shock.

Interaction

Strengthens the arrhythmogenic effect of general anesthetics.

Storage conditions

In a dry place, at a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Siegfried Hameln GmbH, Germany