Etoxidol, 50 mg/ml 2 ml 10 pcs

It is an inhibitor of free radical processes, has membranoprotective, antihypoxic, nootropic, anticonvulsant, anxiolytic effect, increases resistance to stress. It has anti-ischemic properties, improves blood flow in the ischemic area, limits the zone of ischemic damage, has hypolipidemic effect, reduces total cholesterol and low-density lipoproteins. Increases resistance of the body to various damaging factors, to oxygen-dependent pathological states (shock, hypoxia and ischemia, cerebral circulation disorders, intoxication by alcohol and antipsychotic drugs (neuroleptics)).

The effectiveness in encephalopathies is due to the penetration of ethoxidol through the blood-brain barrier. It improves cerebral metabolism and blood supply of the brain, improves microcirculation and blood rheological properties, reduces platelet aggregation. Inhibits lipid peroxidation, increases superoxide dismutase activity, reduces total organic peroxides, increases lipid-protein ratio, reduces membrane viscosity, increases its fluidity. It blocks oxidation of low density lipoproteins.

Modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which helps to maintain the structural and functional organization of biomembranes, transport of neurotransmitters and improves synaptic transmission.

In case of intravenous administration, it is determined in plasma for 4 hours after administration. TCmax – 0.25 h. T1/2 – 1.15-1.75 h. It is excreted by the kidneys, mainly in glucuron-conjugated form and in small amounts unchanged.

Indications

acute cerebral circulation disorders,

dyscirculatory encephalopathy,

vegetative dystonia syndrome,

mild cognitive impairment of atherosclerotic genesis,

/p>

anxiety disorders in neurotic and neurosis-like conditions,

curing withdrawal syndrome in alcoholism with a predominance of neurosis-like and autonomic-vascular disorders,

acute intoxication with antipsychotic drugs.

Active ingredient

Composition

1 ml of solution for intravenous and intramuscular administration contains:

the active ingredient:

ethylmethylhydroxypyridine malate (ethoxidol) 50 mg.

auxiliary substances:

N-acetyl-L-glutamic acid 34 mg,

Deanol (2-(dimethylamino)ethanol) 16 mg,

Glycine 0.1 mg,

dinatrium edetate (dinatrium ethylenediamine-N,N,N’,N’-tetraacetic acid 2-water [trilon B] salt) 0.5 mg,

water for injection up to 1.0 ml

How to take, the dosage

The drug is administered intramuscularly (i.m.) and intravenously (i.v.) (by trickle or drip). During infusion the drug should be diluted in 0.9% sodium chloride solution. Doses shall be selected individually. Start with – 50-100 mg 1-3 times per day, gradually increasing until therapeutic effect is achieved. Slowly by jetting for – 5-7 minutes, or by drip at a rate of 40-60 drops per minute. The maximum dose is 800 mg/day.

In acute disorders of cerebral circulation: in complex therapy in the first 2-4 days v/v (dropwise) – 200-300 mg, then in a/m – 100 mg 3 times/day, 10-14 days.

In dyscirculatory encephalopathy in the decompensation phase and vegetative dystonia syndrome: by IV stream or dropwise – 100 mg 2-3 times/day, 14 days. Then v/m, – 100 mg 2 times/day, 14 days.

For course prophylaxis of dyscirculatory encephalopathy: in/m, – 100 mg 2 times/day, 10-14 days.

In mild cognitive impairment of atherosclerotic genesis and in anxiety disorders with neurotic and neurosis-like conditions: in/m, – 100-300 mg/day, 14-30 days.

When relieving withdrawal syndrome in alcoholism with predominance of neurosis-like and vegetative-vascular disorders: in/m – 100-200 mg 2-3 times/day or by IV drops – 1-2 times/day, 5-7 days.

In acute intoxication with antipsychotic drugs: v/v, – 50-300 mg/day, 7-14 days.

Interaction

It enhances the effect of benzodiazepine anxiolytics, anticonvulsants (carbamazepine), anti-Parkinsonian drugs (levodopa).

Limits the toxic effects of ethyl alcohol.

Special Instructions

During treatment, caution should be exercised when driving vehicles and engaging in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity, acute hepatic and/or renal failure, pregnancy, lactation, age under 18 years.

With caution: Allergic diseases and reactions in the anamnesis.

Side effects

Overdose

Due to the low toxicity of the drug, overdose is unlikely. In case of accidental overdose symptoms of sleep disturbance – somnolence, insomnia are possible.

The treatment is symptomatic.

Pregnancy use

Ethoxidol is contraindicated in pregnancy and lactation, because strictly controlled clinical studies of the safety of the drug in pregnancy and lactation have not been conducted.