Erythromycin-LekT, 250 mg 20 pcs

Interaction

Reduces the bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems).

Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism).

Enhances theophylline concentrations.

Accelerates nephrotoxicity of cyclosporine (especially in patients with concomitant renal failure).

Decreases clearance of triazolam and midazolam and therefore may potentiate the pharmacological effects of benzodiazepines.

Delays elimination (enhances the effect) of methylprednisolone, felodipine and coumarin-type anticoagulants.

The risk of rhabdomyolysis increases when combined with lovastatin, simvastatin and other statins.

Induces bioavailability of digoxin.

Decreases the effectiveness of hormonal contraception.

Drugs that block tubular secretion prolong the T1/2 of Erythromycin.

When co-administered with medicinal products metabolized in the liver by cytochrome P450 system (carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, disopyramide, lovastatin, bromocriptine), the concentration of these medicinal products in plasma may increase (because erythromycin is an inhibitor of liver microsomal enzymes).

In co-administration with terfenadine or astemizole, arrhythmias (ventricular fibrillation and torsade de pointes, ventricular tachycardia, up to death), with dihydroergotamine or unhydrogenated ergot alkaloids – vasoconstriction to complete spasm, dysesthesia may develop.

If you are taking other medications, you should consult your doctor.

Directions for use

Orally (the mode of taking the drug and eating is determined by the dosage form and its resistance to gastric juice). Take the tablet 1-2 hours before a meal or 2-3 hours after a meal. The tablet must not be divided and chewed. A single dose for adults is 250-500 mg. The average daily dose for adults is 1-2 g in 2-4 doses, the maximum daily dose is 4 g.

In children over 14 years old depending on the age, body weight and severity of infection it is 30-50 mg/kg/day in 2-4 doses. In case of severe infections the dose may be doubled. For treatment of diphtheria carrier – 0.25 g 2 times a day.

The course dose for the treatment of primary syphilis is 30-40 g, the duration of treatment is 10-15 days.

In case of amebic dysentery in adults it is 0.25 g 4 times a day, duration of course is 10-14 days.

In legionellosis it is taken 0.5-1 g 4 times a day for 14 days.

In case of gonorrhea – 0.5 g every 6 hours for 3 days, then 0.25 g every 6 hours for 7 days.

In gastroparesis, orally (erythromycin for IV administration) 0.15-0.25 g 30 minutes before meals 3 times daily is preferred for treatment of gastroparesis.

In case of scarlet fever it is used in usual doses; treatment course should be at least 10 days.

In listeriosis – 250-500 mg 4 times a day for at least 7 days, the etiotropic therapy is carried out until the 6th-7th day of normal temperature, and in severe forms – until the 14th-21st day.

In erythrazma – 250 mg 4 times a day for 5-7 days simultaneously with external agents.

For preoperative bowel preparation to prevent infectious complications – orally, 1 g at 19 hours, 18 hours and 9 hours before surgery (total 3 g).

For prevention of streptococcal infection (tonsillitis, pharyngitis) in adults – 20-50 mg/kg/day, in children from 14 years – 20-30 mg/kg/day, the course duration – at least 10 days.

To prevent septic endocarditis in patients with cardiac defects – 1 g for adults and 20 mg/kg for children over 14 years old, 1 hour before therapeutic or diagnostic procedure, further 0.5 g for adults and 10 mg/kg for children, repeated 6 hours later.

In pertussis, 40-50 mg/kg/day for 5-14 days.

In urinary tract infections during pregnancy, 0.5 g 4 times a day for at least 7 days or (if this dose is poorly tolerated) 0.25 g 4 times a day for at least 14 days.

In adults with uncomplicated chlamydia and intolerance to tetracyclines, 0.5 g 4 times daily for at least 7 days.

Special Instructions

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Synopsis

Tablets are round, biconvex, coated with an enteric film, white or grayish-white, cross-section of the core is white or white with a yellowish tint.

Contraindications

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Side effects

Allergic reactions: urticaria, other forms of skin rash, eosinophilia, anaphylactic shock.

Digestive system disorders: nausea, vomiting, gastralgia, abdominal pain, tenesmus, diarrhea, dysbacteriosis, oral candidiasis, pseudomembranous colitis (both during and after treatment), liver dysfunction, cholestatic jaundice, increased activity of “liver” transaminases, pancreatitis.

Hearing organ disorders: decreased hearing and/or tinnitus (when used in high doses – more than 4 g/day, usually reversible).

Cardiovascular system: tachycardia, prolongation of the Q-T interval on electrocardiogram, atrial fibrillation and/or flutter (in patients with prolonged Q-T interval on electrocardiogram).

Overdose

Symptoms: impairment of liver function, up to acute liver failure, hearing loss.

Treatment: activated charcoal, close monitoring of the respiratory system (if necessary – carrying out artificial ventilation), acid-base state and electrolyte metabolism, electrocardiogram.

Gastric lavage is effective at a dose five times the average therapeutic dose.

Hemodialysis, peritoneal dialysis, forced diuresis are ineffective.

Pregnancy use

The use of Erythromycin in pregnancy is possible only when the expected benefits to the mother exceed the potential risk to the fetus.

In lactation due to the possibility of penetration into the breast milk, Erythromycin should be refrained from breastfeeding.

Similarities

Erythromycin ointment, Erythromycin