Enap, tablets 5 mg 20 pcs

How to take, the dosage

The drug Enap is administered orally, regardless of the time of meals. The initial dose of Enap is 10-20 mg per day (once daily).

Thereafter, the dose is adjusted individually for each patient – usually 20 mg once a day.

The maximum daily dose should not exceed 40 mg.

In cases of heart failure, the dose is prescribed starting at 2.5 mg, then the dose is gradually increased to 10 to 20 mg (in one to two doses).

Interaction

The patient should refrain from drinking alcoholic beverages because ethanol increases the reduction of blood pressure (BP) with enalapril.

The concomitant use of enalapril and diuretics or other hypotensive agents increases the effectiveness of these drugs.

The interaction with drugs used to treat heart failure (cardiac glycosides) is not clinically relevant.

Before surgery, the physician should be told that the patient is taking enalapril because of the risk of arterial hypotension during general anesthesia.

The concomitant use of enalapril and nonsteroidal anti-inflammatory drugs (NSAIDs) or acetylsalicylic acid (aspirin) as well as estrogen may decrease the effectiveness of enalapril and increase the risk of renal dysfunction.

The concomitant use of some diuretics (spironolactone, amiloride or triamterene) and/or additional administration of tablets containing potassium may cause increased serum potassium levels (hyperkalemia).

Drugs that cause bone marrow suppression increase the risk of neutropenia and/or agranulocytosis.

Immunosuppressants, allopurinol, cytostatics increase hematotoxicity.

Enalapril weakens the effect of agents containing theophylline.
Simultaneous use of lithium drugs may increase the side effects of lithium.

The concomitant use of Enap with cimetidine increases the half-life (T 1/2) of Enap. If a patient is already taking the above drugs or is advised to take any of them, they should tell their physician that they are taking Enap.

Special Instructions

With caution use Enap in motorists. When concomitant use with diuretics, beta-blockers the effect of Enap is increased, and with nonsteroidal anti-inflammatory drugs the effect is reduced.

Hypotension (rapid decrease in blood pressure) may be observed (even several hours after the first dose) in patients with severe heart failure or significant renal dysfunction as well as in patients with electrolyte-water balance disorders due to diuretic treatment, salt-free diet, diarrhea, vomiting or patients on hemodialysis. A marked decrease in blood pressure (BP) is usually manifested by nausea, increased heart rate (HR) and fainting.

In the case of arterial hypotension, the patient should be in a horizontal, low-headed position and a doctor should be called.

Contraindications

• high sensitivity to enalapril or other drug components,
• high sensitivity to other ACE inhibitors,
• porphyria,
• patients who have ever had angioedema.

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Side effects

• dry cough,
• pharyngitis,
• laryngitis,
• dizziness when standing upright,

impaired renal function and blood pattern,

• nausea, vomiting, abdominal pain,
• dermal allergic reactions,
• headache, depression, sleep disorders,
• increased blood potassium.

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Overdose

If a patient has taken too many pills in one sitting, a doctor should be called immediately.

Symptoms: excessive decrease in blood pressure (BP) up to the development of collapse, myocardial infarction, acute cerebral circulation disorder or thromboembolic complications, seizures, stupor.

Treatment: the patient is transferred to the horizontal position with a low headboard. In mild cases gastric lavage and oral administration of saline solution are indicated, in more severe cases – measures aimed at stabilization of arterial pressure (BP), IV administration of saline solution, plasma substitutes, if necessary – IV administration of angiotensin II, hemodialysis (elimination rate of enalaprilat – 62 ml/min).

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Similarities

Berlipril 5, Renipril, Enam, Enap, Renitec, Berlipril 20, Berlipril 10, Enalapril Hexal, Enalapril FPO, Enalapril Renewal, Berlipril