Eluphor, 200 mg/5 ml suspension 90 ml

It is assumed that antimicrobial activity of nifuroxazide is caused by the presence of NO2-group in its composition, which causes inhibition of dehydrogenase activity and disrupts protein synthesis in pathogenic bacteria.
Active against Gram-positive microorganisms (Streptococcus aureus, Staphylococcus pyogenes, Clostridium), Gram-negative enterobacteriaceae (Escherihia coli, Salmonella spp, Shigella spp., Klebsiella spp., Enterobacter spp., Vibrio cholerae, Campylobacter jejuni, Edwarsiella, Citrobacter, Yersinia enterocolitica). In acute bacterial diarrhea it restores intestinal eubiosis. In case of infection with enterotropic viruses it prevents the development of bacterial superinfection.

Pharmacokinetics
After oral administration nifuroxazide is practically not absorbed from the digestive tract and its antibacterial effect is exclusively in the intestinal lumen. It is completely eliminated through the gastrointestinal tract. The elimination rate depends both on the dose of the drug and on the motility of the intestinal tract.

Indications

Diarrhea of ​​bacterial origin;
Chronic lesions of the gastrointestinal tract of bacterial etiology, accompanied by dyspeptic symptoms.

Pharmacological effect

Broad-spectrum antimicrobial agent, derivative of 5-nitrofuran.
It is assumed that the antimicrobial activity of nifuroxazide is caused by the presence of a NO2 group in its composition, which inhibits the activity of dehydrogenase and disrupts protein synthesis in pathogenic bacteria.
Active against gram-positive microorganisms (Streptococcus aureus, Staphylococcus pyogenes, Clostridium), gram-negative enterobacteria (Escherihia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobacter spp., Vibrio cholerae, Campylobacter jejuni, Edwarsiella, Citrobacter, Yersinia enterocolitica).
Nifuroxazide has no effect on saprophytic flora and does not disturb the balance of normal intestinal flora. In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics
After oral administration, nifuroxazide is practically not absorbed from the digestive tract, and exerts its antibacterial effect exclusively in the intestinal lumen. Completely excreted through the gastrointestinal tract. The rate of elimination depends both on the dose of the drug and on the motility of the intestinal tract.

Special instructions

When treating diarrhea simultaneously with nifuroxazide therapy, it is necessary to carry out rehydration therapy (oral or intravenous) in accordance with the patient’s condition and the intensity of diarrhea.
The use of alcohol is prohibited during therapy with nifuroxazide.
Before prescribing the suspension to infants, it is necessary to exclude congenital deficiency of enzymes that break down sucrose.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect psychomotor activity and the ability to drive vehicles and operate machinery.

Active ingredient

Nifuroxazide

Composition

5 ml of suspension contain:
Active ingredient: nifuroxazide 200.0 mg
Excipients: sucrose 1000.0 mg, sodium hydroxide 2.0 mg, methyl parahydroxybenzoate 5.0 mg, ethanol 96% 0.05 ml, carbomer 10.5 mg, citric acid 0.75 mg, banana flavor 10.00 mg, water up to 5.0 ml

Contraindications

Hypersensitivity to nitrofuran derivatives or other components of the drug;
Fructose intolerance;
Glucose-galactose malabsorption syndrome, sucrase and isomaltase deficiency;
Neonatal period (up to 1 month), prematurity.

Side Effects

Allergic reactions, nausea, vomiting.

Overdose

The drug is not absorbed from the gastrointestinal tract and does not enter the systemic circulation. Overdose symptoms are not known. If the dose is exceeded, gastric lavage and symptomatic treatment are recommended.

Storage conditions

At temperatures from 15° to 30°C.
Keep out of the reach of children.
An opened bottle should be stored for no more than 7 days.

Shelf life

3 years
Do not use after expiration date.

Manufacturer

Ozon, Russia